Design and Synthesis of Novel Betulin Derivatives Containing Thio-/Semicarbazone Moieties as Apoptotic Inducers through Mitochindria-Related Pathways

Two new series of betulin derivatives with semicarbazone (7a–g) or thiosemicarbazone (8a–g) groups at the C-28 position were synthesized. All compounds were evaluated for their in vitro cytotoxicities in human hepatocellular carcinoma cells (HepG2), human breast carcinoma cells (MCF-7), human lung c...

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Detalles Bibliográficos
Autores principales: Wang, Jiafeng, Wu, Jiale, Han, Yinglong, Zhang, Jie, Lin, Yu, Wang, Haijun, Wang, Jing, Liu, Jicheng, Bu, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587101/
https://www.ncbi.nlm.nih.gov/pubmed/34770765
http://dx.doi.org/10.3390/molecules26216356

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