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A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses
A novel human coronavirus prompted considerable worry at the end of the year 2019. Now, it represents a significant global health and economic burden. The newly emerged coronavirus disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the primary reason for the COVID-...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587140/ https://www.ncbi.nlm.nih.gov/pubmed/34770863 http://dx.doi.org/10.3390/molecules26216455 |
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author | Nassar, Aaya Ibrahim, Ibrahim M. Amin, Fatma G. Magdy, Merna Elgharib, Ahmed M. Azzam, Eman B. Nasser, Filopateer Yousry, Kirllos Shamkh, Israa M. Mahdy, Samah M. Elfiky, Abdo A. |
author_facet | Nassar, Aaya Ibrahim, Ibrahim M. Amin, Fatma G. Magdy, Merna Elgharib, Ahmed M. Azzam, Eman B. Nasser, Filopateer Yousry, Kirllos Shamkh, Israa M. Mahdy, Samah M. Elfiky, Abdo A. |
author_sort | Nassar, Aaya |
collection | PubMed |
description | A novel human coronavirus prompted considerable worry at the end of the year 2019. Now, it represents a significant global health and economic burden. The newly emerged coronavirus disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the primary reason for the COVID-19 global pandemic. According to recent global figures, COVID-19 has caused approximately 243.3 million illnesses and 4.9 million deaths. Several human cell receptors are involved in the virus identification of the host cells and entering them. Hence, understanding how the virus binds to host-cell receptors is crucial for developing antiviral treatments and vaccines. The current work aimed to determine the multiple host-cell receptors that bind with SARS-CoV-2 and other human coronaviruses for the purpose of cell entry. Extensive research is needed using neutralizing antibodies, natural chemicals, and therapeutic peptides to target those host-cell receptors in extremely susceptible individuals. More research is needed to map SARS-CoV-2 cell entry pathways in order to identify potential viral inhibitors. |
format | Online Article Text |
id | pubmed-8587140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85871402021-11-13 A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses Nassar, Aaya Ibrahim, Ibrahim M. Amin, Fatma G. Magdy, Merna Elgharib, Ahmed M. Azzam, Eman B. Nasser, Filopateer Yousry, Kirllos Shamkh, Israa M. Mahdy, Samah M. Elfiky, Abdo A. Molecules Review A novel human coronavirus prompted considerable worry at the end of the year 2019. Now, it represents a significant global health and economic burden. The newly emerged coronavirus disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the primary reason for the COVID-19 global pandemic. According to recent global figures, COVID-19 has caused approximately 243.3 million illnesses and 4.9 million deaths. Several human cell receptors are involved in the virus identification of the host cells and entering them. Hence, understanding how the virus binds to host-cell receptors is crucial for developing antiviral treatments and vaccines. The current work aimed to determine the multiple host-cell receptors that bind with SARS-CoV-2 and other human coronaviruses for the purpose of cell entry. Extensive research is needed using neutralizing antibodies, natural chemicals, and therapeutic peptides to target those host-cell receptors in extremely susceptible individuals. More research is needed to map SARS-CoV-2 cell entry pathways in order to identify potential viral inhibitors. MDPI 2021-10-26 /pmc/articles/PMC8587140/ /pubmed/34770863 http://dx.doi.org/10.3390/molecules26216455 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nassar, Aaya Ibrahim, Ibrahim M. Amin, Fatma G. Magdy, Merna Elgharib, Ahmed M. Azzam, Eman B. Nasser, Filopateer Yousry, Kirllos Shamkh, Israa M. Mahdy, Samah M. Elfiky, Abdo A. A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses |
title | A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses |
title_full | A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses |
title_fullStr | A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses |
title_full_unstemmed | A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses |
title_short | A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses |
title_sort | review of human coronaviruses’ receptors: the host-cell targets for the crown bearing viruses |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587140/ https://www.ncbi.nlm.nih.gov/pubmed/34770863 http://dx.doi.org/10.3390/molecules26216455 |
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