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Anti-C2 Antibody ARGX-117 Inhibits Complement in a Disease Model for Multifocal Motor Neuropathy

BACKGROUND AND OBJECTIVES: To determine the role of complement in the disease pathology of multifocal motor neuropathy (MMN), we investigated complement activation, and inhibition, on binding of MMN patient-derived immunoglobulin M (IgM) antibodies in an induced pluripotent stem cell (iPSC)-derived...

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Detalles Bibliográficos
Autores principales:	Budding, Kevin, Johansen, Lill Eva, Van de Walle, Inge, Dijkxhoorn, Kim, de Zeeuw, Elisabeth, Bloemenkamp, Lauri M., Bos, Jeroen W., Jansen, Marc D., Curial, Chantall A.D., Silence, Karen, de Haard, Hans, Blanchetot, Christophe, Van de Ven, Liesbeth, Leusen, Jeanette H.W., Pasterkamp, R. Jeroen, van den Berg, Leonard H., Hack, C. Erik, Boross, Peter, van der Pol, W. Ludo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587732/ https://www.ncbi.nlm.nih.gov/pubmed/34759020 http://dx.doi.org/10.1212/NXI.0000000000001107

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