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Bodiniosides S–Y, Seven New Triterpenoid Saponins from Elsholtzia bodinieri and Their Anti-Influenza Activities

Investigation of the n-BuOH extract of the aerial parts of Elsholtzia bodinieri led to the isolation of seven new triterpenoid saponins, Bodiniosides S–Y (1–7, resp.). Their strictures were elucidated on the basis of spectroscopic techniques, including HSQC, HSBC, and HSQC–TOCSY experiments, togethe...

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Detalles Bibliográficos
Autores principales: Yang, Linyao, Du, Jiangchao, Li, Rongtao, Yu, Fei, Zhong, Jindong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587758/
https://www.ncbi.nlm.nih.gov/pubmed/34770944
http://dx.doi.org/10.3390/molecules26216535
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author Yang, Linyao
Du, Jiangchao
Li, Rongtao
Yu, Fei
Zhong, Jindong
author_facet Yang, Linyao
Du, Jiangchao
Li, Rongtao
Yu, Fei
Zhong, Jindong
author_sort Yang, Linyao
collection PubMed
description Investigation of the n-BuOH extract of the aerial parts of Elsholtzia bodinieri led to the isolation of seven new triterpenoid saponins, Bodiniosides S–Y (1–7, resp.). Their strictures were elucidated on the basis of spectroscopic techniques, including HSQC, HSBC, and HSQC–TOCSY experiments, together with acid hydrolysis and GC analysis. The anti-influenza activities of compounds 1–7 were evaluated against A/WSN/33/2009 (H1N1) virus in MDCK cells. The results showed that compounds 2 and 5 exhibited moderate anti-influenza activities against A/WSN/33/2009 (H1N1), with inhibition rates of 35.33% and 24.08%, respectively.
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spelling pubmed-85877582021-11-13 Bodiniosides S–Y, Seven New Triterpenoid Saponins from Elsholtzia bodinieri and Their Anti-Influenza Activities Yang, Linyao Du, Jiangchao Li, Rongtao Yu, Fei Zhong, Jindong Molecules Article Investigation of the n-BuOH extract of the aerial parts of Elsholtzia bodinieri led to the isolation of seven new triterpenoid saponins, Bodiniosides S–Y (1–7, resp.). Their strictures were elucidated on the basis of spectroscopic techniques, including HSQC, HSBC, and HSQC–TOCSY experiments, together with acid hydrolysis and GC analysis. The anti-influenza activities of compounds 1–7 were evaluated against A/WSN/33/2009 (H1N1) virus in MDCK cells. The results showed that compounds 2 and 5 exhibited moderate anti-influenza activities against A/WSN/33/2009 (H1N1), with inhibition rates of 35.33% and 24.08%, respectively. MDPI 2021-10-29 /pmc/articles/PMC8587758/ /pubmed/34770944 http://dx.doi.org/10.3390/molecules26216535 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Linyao
Du, Jiangchao
Li, Rongtao
Yu, Fei
Zhong, Jindong
Bodiniosides S–Y, Seven New Triterpenoid Saponins from Elsholtzia bodinieri and Their Anti-Influenza Activities
title Bodiniosides S–Y, Seven New Triterpenoid Saponins from Elsholtzia bodinieri and Their Anti-Influenza Activities
title_full Bodiniosides S–Y, Seven New Triterpenoid Saponins from Elsholtzia bodinieri and Their Anti-Influenza Activities
title_fullStr Bodiniosides S–Y, Seven New Triterpenoid Saponins from Elsholtzia bodinieri and Their Anti-Influenza Activities
title_full_unstemmed Bodiniosides S–Y, Seven New Triterpenoid Saponins from Elsholtzia bodinieri and Their Anti-Influenza Activities
title_short Bodiniosides S–Y, Seven New Triterpenoid Saponins from Elsholtzia bodinieri and Their Anti-Influenza Activities
title_sort bodiniosides s–y, seven new triterpenoid saponins from elsholtzia bodinieri and their anti-influenza activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587758/
https://www.ncbi.nlm.nih.gov/pubmed/34770944
http://dx.doi.org/10.3390/molecules26216535
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