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Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

Polymeric hydrogels are widely explored materials for biomedical applications. However, they have inherent limitations like poor resistance to stimuli and low mechanical strength. This drawback of hydrogels gave rise to ‘‘smart self-healing hydrogels’’ which autonomously repair themselves when ruptu...

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Autores principales: Devi V. K., Anupama, Shyam, Rohin, Palaniappan, Arunkumar, Jaiswal, Amit Kumar, Oh, Tae-Hwan, Nathanael, Arputharaj Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587783/
https://www.ncbi.nlm.nih.gov/pubmed/34771338
http://dx.doi.org/10.3390/polym13213782
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author Devi V. K., Anupama
Shyam, Rohin
Palaniappan, Arunkumar
Jaiswal, Amit Kumar
Oh, Tae-Hwan
Nathanael, Arputharaj Joseph
author_facet Devi V. K., Anupama
Shyam, Rohin
Palaniappan, Arunkumar
Jaiswal, Amit Kumar
Oh, Tae-Hwan
Nathanael, Arputharaj Joseph
author_sort Devi V. K., Anupama
collection PubMed
description Polymeric hydrogels are widely explored materials for biomedical applications. However, they have inherent limitations like poor resistance to stimuli and low mechanical strength. This drawback of hydrogels gave rise to ‘‘smart self-healing hydrogels’’ which autonomously repair themselves when ruptured or traumatized. It is superior in terms of durability and stability due to its capacity to reform its shape, injectability, and stretchability thereby regaining back the original mechanical property. This review focuses on various self-healing mechanisms (covalent and non-covalent interactions) of these hydrogels, methods used to evaluate their self-healing properties, and their applications in wound healing, drug delivery, cell encapsulation, and tissue engineering systems. Furthermore, composite materials are used to enhance the hydrogel’s mechanical properties. Hence, findings of research with various composite materials are briefly discussed in order to emphasize the healing capacity of such hydrogels. Additionally, various methods to evaluate the self-healing properties of hydrogels and their recent advancements towards 3D bioprinting are also reviewed. The review is concluded by proposing several pertinent challenges encountered at present as well as some prominent future perspectives.
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spelling pubmed-85877832021-11-13 Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications Devi V. K., Anupama Shyam, Rohin Palaniappan, Arunkumar Jaiswal, Amit Kumar Oh, Tae-Hwan Nathanael, Arputharaj Joseph Polymers (Basel) Review Polymeric hydrogels are widely explored materials for biomedical applications. However, they have inherent limitations like poor resistance to stimuli and low mechanical strength. This drawback of hydrogels gave rise to ‘‘smart self-healing hydrogels’’ which autonomously repair themselves when ruptured or traumatized. It is superior in terms of durability and stability due to its capacity to reform its shape, injectability, and stretchability thereby regaining back the original mechanical property. This review focuses on various self-healing mechanisms (covalent and non-covalent interactions) of these hydrogels, methods used to evaluate their self-healing properties, and their applications in wound healing, drug delivery, cell encapsulation, and tissue engineering systems. Furthermore, composite materials are used to enhance the hydrogel’s mechanical properties. Hence, findings of research with various composite materials are briefly discussed in order to emphasize the healing capacity of such hydrogels. Additionally, various methods to evaluate the self-healing properties of hydrogels and their recent advancements towards 3D bioprinting are also reviewed. The review is concluded by proposing several pertinent challenges encountered at present as well as some prominent future perspectives. MDPI 2021-10-31 /pmc/articles/PMC8587783/ /pubmed/34771338 http://dx.doi.org/10.3390/polym13213782 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Devi V. K., Anupama
Shyam, Rohin
Palaniappan, Arunkumar
Jaiswal, Amit Kumar
Oh, Tae-Hwan
Nathanael, Arputharaj Joseph
Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications
title Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications
title_full Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications
title_fullStr Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications
title_full_unstemmed Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications
title_short Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications
title_sort self-healing hydrogels: preparation, mechanism and advancement in biomedical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587783/
https://www.ncbi.nlm.nih.gov/pubmed/34771338
http://dx.doi.org/10.3390/polym13213782
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