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Recent Advances on Functional Nucleic-Acid Biosensors

In the past few decades, biosensors have been gradually developed for the rapid detection and monitoring of human diseases. Recently, functional nucleic-acid (FNA) biosensors have attracted the attention of scholars due to a series of advantages such as high stability and strong specificity, as well...

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Autores principales: Yu, Xinhong, Zhang, Shiqi, Guo, Wenqiang, Li, Boxi, Yang, Yang, Xie, Bingqing, Li, Ke, Zhang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587875/
https://www.ncbi.nlm.nih.gov/pubmed/34770415
http://dx.doi.org/10.3390/s21217109
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author Yu, Xinhong
Zhang, Shiqi
Guo, Wenqiang
Li, Boxi
Yang, Yang
Xie, Bingqing
Li, Ke
Zhang, Li
author_facet Yu, Xinhong
Zhang, Shiqi
Guo, Wenqiang
Li, Boxi
Yang, Yang
Xie, Bingqing
Li, Ke
Zhang, Li
author_sort Yu, Xinhong
collection PubMed
description In the past few decades, biosensors have been gradually developed for the rapid detection and monitoring of human diseases. Recently, functional nucleic-acid (FNA) biosensors have attracted the attention of scholars due to a series of advantages such as high stability and strong specificity, as well as the significant progress they have made in terms of biomedical applications. However, there are few reports that systematically and comprehensively summarize its working principles, classification and application. In this review, we primarily introduce functional modes of biosensors that combine functional nucleic acids with different signal output modes. In addition, the mechanisms of action of several media of the FNA biosensor are introduced. Finally, the practical application and existing problems of FNA sensors are discussed, and the future development directions and application prospects of functional nucleic acid sensors are prospected.
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spelling pubmed-85878752021-11-13 Recent Advances on Functional Nucleic-Acid Biosensors Yu, Xinhong Zhang, Shiqi Guo, Wenqiang Li, Boxi Yang, Yang Xie, Bingqing Li, Ke Zhang, Li Sensors (Basel) Review In the past few decades, biosensors have been gradually developed for the rapid detection and monitoring of human diseases. Recently, functional nucleic-acid (FNA) biosensors have attracted the attention of scholars due to a series of advantages such as high stability and strong specificity, as well as the significant progress they have made in terms of biomedical applications. However, there are few reports that systematically and comprehensively summarize its working principles, classification and application. In this review, we primarily introduce functional modes of biosensors that combine functional nucleic acids with different signal output modes. In addition, the mechanisms of action of several media of the FNA biosensor are introduced. Finally, the practical application and existing problems of FNA sensors are discussed, and the future development directions and application prospects of functional nucleic acid sensors are prospected. MDPI 2021-10-26 /pmc/articles/PMC8587875/ /pubmed/34770415 http://dx.doi.org/10.3390/s21217109 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yu, Xinhong
Zhang, Shiqi
Guo, Wenqiang
Li, Boxi
Yang, Yang
Xie, Bingqing
Li, Ke
Zhang, Li
Recent Advances on Functional Nucleic-Acid Biosensors
title Recent Advances on Functional Nucleic-Acid Biosensors
title_full Recent Advances on Functional Nucleic-Acid Biosensors
title_fullStr Recent Advances on Functional Nucleic-Acid Biosensors
title_full_unstemmed Recent Advances on Functional Nucleic-Acid Biosensors
title_short Recent Advances on Functional Nucleic-Acid Biosensors
title_sort recent advances on functional nucleic-acid biosensors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587875/
https://www.ncbi.nlm.nih.gov/pubmed/34770415
http://dx.doi.org/10.3390/s21217109
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