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Biosynthetic Mechanisms and Biological Significance of Glycerol Phosphate-Containing Glycan in Mammals
Bacteria contain glycerol phosphate (GroP)-containing glycans, which are important constituents of cell-surface glycopolymers such as the teichoic acids of Gram-positive bacterial cell walls. These glycopolymers comprising GroP play crucial roles in bacterial physiology and virulence. Recently, the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587909/ https://www.ncbi.nlm.nih.gov/pubmed/34771084 http://dx.doi.org/10.3390/molecules26216675 |
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author | Imae, Rieko Manya, Hiroshi Endo, Tamao |
author_facet | Imae, Rieko Manya, Hiroshi Endo, Tamao |
author_sort | Imae, Rieko |
collection | PubMed |
description | Bacteria contain glycerol phosphate (GroP)-containing glycans, which are important constituents of cell-surface glycopolymers such as the teichoic acids of Gram-positive bacterial cell walls. These glycopolymers comprising GroP play crucial roles in bacterial physiology and virulence. Recently, the first identification of a GroP-containing glycan in mammals was reported as a variant form of O-mannosyl glycan on α-dystroglycan (α-DG). However, the biological significance of such GroP modification remains largely unknown. In this review, we provide an overview of this new discovery of GroP-containing glycan in mammals and then outline the recent progress in elucidating the biosynthetic mechanisms of GroP-containing glycans on α-DG. In addition, we discuss the potential biological role of GroP modification along with the challenges and prospects for further research. The progress in this newly identified glycan modification will provide insights into the phylogenetic implications of glycan. |
format | Online Article Text |
id | pubmed-8587909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85879092021-11-13 Biosynthetic Mechanisms and Biological Significance of Glycerol Phosphate-Containing Glycan in Mammals Imae, Rieko Manya, Hiroshi Endo, Tamao Molecules Review Bacteria contain glycerol phosphate (GroP)-containing glycans, which are important constituents of cell-surface glycopolymers such as the teichoic acids of Gram-positive bacterial cell walls. These glycopolymers comprising GroP play crucial roles in bacterial physiology and virulence. Recently, the first identification of a GroP-containing glycan in mammals was reported as a variant form of O-mannosyl glycan on α-dystroglycan (α-DG). However, the biological significance of such GroP modification remains largely unknown. In this review, we provide an overview of this new discovery of GroP-containing glycan in mammals and then outline the recent progress in elucidating the biosynthetic mechanisms of GroP-containing glycans on α-DG. In addition, we discuss the potential biological role of GroP modification along with the challenges and prospects for further research. The progress in this newly identified glycan modification will provide insights into the phylogenetic implications of glycan. MDPI 2021-11-04 /pmc/articles/PMC8587909/ /pubmed/34771084 http://dx.doi.org/10.3390/molecules26216675 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Imae, Rieko Manya, Hiroshi Endo, Tamao Biosynthetic Mechanisms and Biological Significance of Glycerol Phosphate-Containing Glycan in Mammals |
title | Biosynthetic Mechanisms and Biological Significance of Glycerol Phosphate-Containing Glycan in Mammals |
title_full | Biosynthetic Mechanisms and Biological Significance of Glycerol Phosphate-Containing Glycan in Mammals |
title_fullStr | Biosynthetic Mechanisms and Biological Significance of Glycerol Phosphate-Containing Glycan in Mammals |
title_full_unstemmed | Biosynthetic Mechanisms and Biological Significance of Glycerol Phosphate-Containing Glycan in Mammals |
title_short | Biosynthetic Mechanisms and Biological Significance of Glycerol Phosphate-Containing Glycan in Mammals |
title_sort | biosynthetic mechanisms and biological significance of glycerol phosphate-containing glycan in mammals |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587909/ https://www.ncbi.nlm.nih.gov/pubmed/34771084 http://dx.doi.org/10.3390/molecules26216675 |
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