Amide-Assisted Rearrangement of Hydroxyarylformimidoyl Chloride to Diarylurea

A novel amide-assisted rearrangement reaction of hydroxybenzimidoyl chloride has been established for the efficient synthesis of 1,3-diphenylurea derivatives. A variety of electronically and sterically different 1,3-diphenylurea derivatives can be obtained in good to excellent yields, and a proposed...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Xizhong, Liu, Xiaoyu, Yu, Wei, Jin, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587945/
https://www.ncbi.nlm.nih.gov/pubmed/34770846
http://dx.doi.org/10.3390/molecules26216437
_version_ 1784598306105589760
author Song, Xizhong
Liu, Xiaoyu
Yu, Wei
Jin, Yi
author_facet Song, Xizhong
Liu, Xiaoyu
Yu, Wei
Jin, Yi
author_sort Song, Xizhong
collection PubMed
description A novel amide-assisted rearrangement reaction of hydroxybenzimidoyl chloride has been established for the efficient synthesis of 1,3-diphenylurea derivatives. A variety of electronically and sterically different 1,3-diphenylurea derivatives can be obtained in good to excellent yields, and a proposed reaction mechanism is also presented.
format Online
Article
Text
id pubmed-8587945
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85879452021-11-13 Amide-Assisted Rearrangement of Hydroxyarylformimidoyl Chloride to Diarylurea Song, Xizhong Liu, Xiaoyu Yu, Wei Jin, Yi Molecules Communication A novel amide-assisted rearrangement reaction of hydroxybenzimidoyl chloride has been established for the efficient synthesis of 1,3-diphenylurea derivatives. A variety of electronically and sterically different 1,3-diphenylurea derivatives can be obtained in good to excellent yields, and a proposed reaction mechanism is also presented. MDPI 2021-10-25 /pmc/articles/PMC8587945/ /pubmed/34770846 http://dx.doi.org/10.3390/molecules26216437 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Song, Xizhong
Liu, Xiaoyu
Yu, Wei
Jin, Yi
Amide-Assisted Rearrangement of Hydroxyarylformimidoyl Chloride to Diarylurea
title Amide-Assisted Rearrangement of Hydroxyarylformimidoyl Chloride to Diarylurea
title_full Amide-Assisted Rearrangement of Hydroxyarylformimidoyl Chloride to Diarylurea
title_fullStr Amide-Assisted Rearrangement of Hydroxyarylformimidoyl Chloride to Diarylurea
title_full_unstemmed Amide-Assisted Rearrangement of Hydroxyarylformimidoyl Chloride to Diarylurea
title_short Amide-Assisted Rearrangement of Hydroxyarylformimidoyl Chloride to Diarylurea
title_sort amide-assisted rearrangement of hydroxyarylformimidoyl chloride to diarylurea
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587945/
https://www.ncbi.nlm.nih.gov/pubmed/34770846
http://dx.doi.org/10.3390/molecules26216437
work_keys_str_mv AT songxizhong amideassistedrearrangementofhydroxyarylformimidoylchloridetodiarylurea
AT liuxiaoyu amideassistedrearrangementofhydroxyarylformimidoylchloridetodiarylurea
AT yuwei amideassistedrearrangementofhydroxyarylformimidoylchloridetodiarylurea
AT jinyi amideassistedrearrangementofhydroxyarylformimidoylchloridetodiarylurea

Ejemplares similares