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Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials
Here we report on the synthesis and characterization of three new N-modified analogues of hemorphin-4 with rhodamine B. Modified with chloroacetyl, chloride cotton fabric has been dyed and color coordinates of the obtained textile materials were determined. Antiviral and virucidal activities of both...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587962/ https://www.ncbi.nlm.nih.gov/pubmed/34771015 http://dx.doi.org/10.3390/molecules26216608 |
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author | Todorov, Petar Georgieva, Stela Staneva, Desislava Peneva, Petia Grozdanov, Petar Nikolova, Ivanka Grabchev, Ivo |
author_facet | Todorov, Petar Georgieva, Stela Staneva, Desislava Peneva, Petia Grozdanov, Petar Nikolova, Ivanka Grabchev, Ivo |
author_sort | Todorov, Petar |
collection | PubMed |
description | Here we report on the synthesis and characterization of three new N-modified analogues of hemorphin-4 with rhodamine B. Modified with chloroacetyl, chloride cotton fabric has been dyed and color coordinates of the obtained textile materials were determined. Antiviral and virucidal activities of both the peptide-rhodamine B compounds and the dyed textile material were studied. Basic physicochemical properties (acid-base behavior, solvent influence, kinetics) related to the elucidation of structural activity of the new modified peptides based on their steric open/closed ring effect were studied. The obtained results lead to the conclusion that in protic solvent with change in pH of the environment, direct control over the dyeing of textiles can be achieved. Both the new hybrid peptide compounds and the modification of functionalized textile materials with these bioactive hemorphins showed virucidal activity against the human respiratory syncytial virus (HRSV-S2) and human adenovirus serotype 5 (HAdV-5) for different time intervals (30 and 60 min) and the most active compound was Rh-3. |
format | Online Article Text |
id | pubmed-8587962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85879622021-11-13 Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials Todorov, Petar Georgieva, Stela Staneva, Desislava Peneva, Petia Grozdanov, Petar Nikolova, Ivanka Grabchev, Ivo Molecules Article Here we report on the synthesis and characterization of three new N-modified analogues of hemorphin-4 with rhodamine B. Modified with chloroacetyl, chloride cotton fabric has been dyed and color coordinates of the obtained textile materials were determined. Antiviral and virucidal activities of both the peptide-rhodamine B compounds and the dyed textile material were studied. Basic physicochemical properties (acid-base behavior, solvent influence, kinetics) related to the elucidation of structural activity of the new modified peptides based on their steric open/closed ring effect were studied. The obtained results lead to the conclusion that in protic solvent with change in pH of the environment, direct control over the dyeing of textiles can be achieved. Both the new hybrid peptide compounds and the modification of functionalized textile materials with these bioactive hemorphins showed virucidal activity against the human respiratory syncytial virus (HRSV-S2) and human adenovirus serotype 5 (HAdV-5) for different time intervals (30 and 60 min) and the most active compound was Rh-3. MDPI 2021-10-31 /pmc/articles/PMC8587962/ /pubmed/34771015 http://dx.doi.org/10.3390/molecules26216608 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Todorov, Petar Georgieva, Stela Staneva, Desislava Peneva, Petia Grozdanov, Petar Nikolova, Ivanka Grabchev, Ivo Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials |
title | Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials |
title_full | Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials |
title_fullStr | Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials |
title_full_unstemmed | Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials |
title_short | Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials |
title_sort | synthesis of new modified with rhodamine b peptides for antiviral protection of textile materials |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587962/ https://www.ncbi.nlm.nih.gov/pubmed/34771015 http://dx.doi.org/10.3390/molecules26216608 |
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