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Proteomic Research on the Antitumor Properties of Medicinal Mushrooms

Medicinal mushrooms are increasingly being recognized as an important therapeutic modality in complementary oncology. Until now, more than 800 mushroom species have been known to possess significant pharmacological properties, of which antitumor and immunomodulatory properties have been the most res...

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Detalles Bibliográficos
Autores principales: Jakopovic, Boris, Oršolić, Nada, Jakopovich, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588050/
https://www.ncbi.nlm.nih.gov/pubmed/34771120
http://dx.doi.org/10.3390/molecules26216708
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author Jakopovic, Boris
Oršolić, Nada
Jakopovich, Ivan
author_facet Jakopovic, Boris
Oršolić, Nada
Jakopovich, Ivan
author_sort Jakopovic, Boris
collection PubMed
description Medicinal mushrooms are increasingly being recognized as an important therapeutic modality in complementary oncology. Until now, more than 800 mushroom species have been known to possess significant pharmacological properties, of which antitumor and immunomodulatory properties have been the most researched. Besides a number of medicinal mushroom preparations being used as dietary supplements and nutraceuticals, several isolates from mushrooms have been used as official antitumor drugs in clinical settings for several decades. Various proteomic approaches allow for the identification of a large number of differentially regulated proteins serendipitously, thereby providing an important platform for a discovery of new potential therapeutic targets and approaches as well as biomarkers of malignant disease. This review is focused on the current state of proteomic research into antitumor mechanisms of some of the most researched medicinal mushroom species, including Phellinus linteus, Ganoderma lucidum, Auricularia auricula, Agrocybe aegerita, Grifola frondosa, and Lentinus edodes, as whole body extracts or various isolates, as well as of complex extract mixtures.
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spelling pubmed-85880502021-11-13 Proteomic Research on the Antitumor Properties of Medicinal Mushrooms Jakopovic, Boris Oršolić, Nada Jakopovich, Ivan Molecules Review Medicinal mushrooms are increasingly being recognized as an important therapeutic modality in complementary oncology. Until now, more than 800 mushroom species have been known to possess significant pharmacological properties, of which antitumor and immunomodulatory properties have been the most researched. Besides a number of medicinal mushroom preparations being used as dietary supplements and nutraceuticals, several isolates from mushrooms have been used as official antitumor drugs in clinical settings for several decades. Various proteomic approaches allow for the identification of a large number of differentially regulated proteins serendipitously, thereby providing an important platform for a discovery of new potential therapeutic targets and approaches as well as biomarkers of malignant disease. This review is focused on the current state of proteomic research into antitumor mechanisms of some of the most researched medicinal mushroom species, including Phellinus linteus, Ganoderma lucidum, Auricularia auricula, Agrocybe aegerita, Grifola frondosa, and Lentinus edodes, as whole body extracts or various isolates, as well as of complex extract mixtures. MDPI 2021-11-05 /pmc/articles/PMC8588050/ /pubmed/34771120 http://dx.doi.org/10.3390/molecules26216708 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jakopovic, Boris
Oršolić, Nada
Jakopovich, Ivan
Proteomic Research on the Antitumor Properties of Medicinal Mushrooms
title Proteomic Research on the Antitumor Properties of Medicinal Mushrooms
title_full Proteomic Research on the Antitumor Properties of Medicinal Mushrooms
title_fullStr Proteomic Research on the Antitumor Properties of Medicinal Mushrooms
title_full_unstemmed Proteomic Research on the Antitumor Properties of Medicinal Mushrooms
title_short Proteomic Research on the Antitumor Properties of Medicinal Mushrooms
title_sort proteomic research on the antitumor properties of medicinal mushrooms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588050/
https://www.ncbi.nlm.nih.gov/pubmed/34771120
http://dx.doi.org/10.3390/molecules26216708
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