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Recognizing a MIS-Chievous Cause of Acute Viral Gastroenteritis
Historically, children evaluated for vomiting and diarrhea secondary to viral enteritis have symptoms lasting 2–4 days and respond to supportive care, including oral rehydration and anti-emetics if required. Recently, within a 14-day timespan, we encountered three children with severe diarrhea who r...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588082/ https://www.ncbi.nlm.nih.gov/pubmed/34778138 http://dx.doi.org/10.3389/fped.2021.748368 |
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author | Josyabhatla, Rohit Kamdar, Ankur A. Armbrister, Shabba A. Daniel, Rhea Boukas, Konstantinos Smith, Keely G. Van Arsdall, Melissa R. Kakarala, Kokila Flores, Anthony R. Wanger, Audrey Liu, Yuying Rhoads, Jon Marc |
author_facet | Josyabhatla, Rohit Kamdar, Ankur A. Armbrister, Shabba A. Daniel, Rhea Boukas, Konstantinos Smith, Keely G. Van Arsdall, Melissa R. Kakarala, Kokila Flores, Anthony R. Wanger, Audrey Liu, Yuying Rhoads, Jon Marc |
author_sort | Josyabhatla, Rohit |
collection | PubMed |
description | Historically, children evaluated for vomiting and diarrhea secondary to viral enteritis have symptoms lasting 2–4 days and respond to supportive care, including oral rehydration and anti-emetics if required. Recently, within a 14-day timespan, we encountered three children with severe diarrhea who rapidly became dehydrated and went into hypotensive shock. Although SARS-CoV-2 molecular tests were negative by nasopharyngeal swab, all were later found to have MIS-C. This small case series underscores features reported in previous larger studies and emphasizes the rapid clinical evolution of this condition. We highlight the importance of early recognition of cardinal laboratory findings characteristic of MIS-C (i.e., lymphopenia, markedly elevated acute phase reactants, and hypoalbuminemia). We also show serologic evidence that the pathophysiological mechanism of SARS-CoV-2 related diarrhea may differ from other causes of dehydrating vomiting and diarrhea, with no serologic evidence of villus cell injury. |
format | Online Article Text |
id | pubmed-8588082 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85880822021-11-13 Recognizing a MIS-Chievous Cause of Acute Viral Gastroenteritis Josyabhatla, Rohit Kamdar, Ankur A. Armbrister, Shabba A. Daniel, Rhea Boukas, Konstantinos Smith, Keely G. Van Arsdall, Melissa R. Kakarala, Kokila Flores, Anthony R. Wanger, Audrey Liu, Yuying Rhoads, Jon Marc Front Pediatr Pediatrics Historically, children evaluated for vomiting and diarrhea secondary to viral enteritis have symptoms lasting 2–4 days and respond to supportive care, including oral rehydration and anti-emetics if required. Recently, within a 14-day timespan, we encountered three children with severe diarrhea who rapidly became dehydrated and went into hypotensive shock. Although SARS-CoV-2 molecular tests were negative by nasopharyngeal swab, all were later found to have MIS-C. This small case series underscores features reported in previous larger studies and emphasizes the rapid clinical evolution of this condition. We highlight the importance of early recognition of cardinal laboratory findings characteristic of MIS-C (i.e., lymphopenia, markedly elevated acute phase reactants, and hypoalbuminemia). We also show serologic evidence that the pathophysiological mechanism of SARS-CoV-2 related diarrhea may differ from other causes of dehydrating vomiting and diarrhea, with no serologic evidence of villus cell injury. Frontiers Media S.A. 2021-10-29 /pmc/articles/PMC8588082/ /pubmed/34778138 http://dx.doi.org/10.3389/fped.2021.748368 Text en Copyright © 2021 Josyabhatla, Kamdar, Armbrister, Daniel, Boukas, Smith, Van Arsdall, Kakarala, Flores, Wanger, Liu and Rhoads. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Josyabhatla, Rohit Kamdar, Ankur A. Armbrister, Shabba A. Daniel, Rhea Boukas, Konstantinos Smith, Keely G. Van Arsdall, Melissa R. Kakarala, Kokila Flores, Anthony R. Wanger, Audrey Liu, Yuying Rhoads, Jon Marc Recognizing a MIS-Chievous Cause of Acute Viral Gastroenteritis |
title | Recognizing a MIS-Chievous Cause of Acute Viral Gastroenteritis |
title_full | Recognizing a MIS-Chievous Cause of Acute Viral Gastroenteritis |
title_fullStr | Recognizing a MIS-Chievous Cause of Acute Viral Gastroenteritis |
title_full_unstemmed | Recognizing a MIS-Chievous Cause of Acute Viral Gastroenteritis |
title_short | Recognizing a MIS-Chievous Cause of Acute Viral Gastroenteritis |
title_sort | recognizing a mis-chievous cause of acute viral gastroenteritis |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588082/ https://www.ncbi.nlm.nih.gov/pubmed/34778138 http://dx.doi.org/10.3389/fped.2021.748368 |
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