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Rapid Detection of Coronavirus (COVID-19) Using Microwave Immunosensor Cavity Resonator

This paper presents a rapid diagnostic device for the detection of the pandemic coronavirus (COVID-19) using a micro-immunosensor cavity resonator. Coronavirus has been declared an international public health crisis, so it is important to design quick diagnostic methods for the detection of infected...

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Autores principales: Elsheakh, Dalia M., Ahmed, Mohamed I., Elashry, Gomaa M., Moghannem, Saad M., Elsadek, Hala A., Elmazny, Waleed N., Alieldin, Nelly H., Abdallah, Esmat A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588152/
https://www.ncbi.nlm.nih.gov/pubmed/34770328
http://dx.doi.org/10.3390/s21217021
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author Elsheakh, Dalia M.
Ahmed, Mohamed I.
Elashry, Gomaa M.
Moghannem, Saad M.
Elsadek, Hala A.
Elmazny, Waleed N.
Alieldin, Nelly H.
Abdallah, Esmat A.
author_facet Elsheakh, Dalia M.
Ahmed, Mohamed I.
Elashry, Gomaa M.
Moghannem, Saad M.
Elsadek, Hala A.
Elmazny, Waleed N.
Alieldin, Nelly H.
Abdallah, Esmat A.
author_sort Elsheakh, Dalia M.
collection PubMed
description This paper presents a rapid diagnostic device for the detection of the pandemic coronavirus (COVID-19) using a micro-immunosensor cavity resonator. Coronavirus has been declared an international public health crisis, so it is important to design quick diagnostic methods for the detection of infected cases, especially in rural areas, to limit the spread of the virus. Herein, a proof-of-concept is presented for a portable laboratory device for the detection of the SARS-CoV-2 virus using electromagnetic biosensors. This device is a microwave cavity resonator (MCR) composed of a sensor operating at industrial, scientific and medical (ISM) 2.45 GHz inserted in 3D housing. The changes of electrical properties of measured serum samples after passing the sensor surface are presented. The three change parameters of the sensor are resonating frequency value, amplitude and phase of the reflection coefficient |S(11)|. This immune-sensor offers a portable, rapid and accurate diagnostic method for the SARS-CoV-2 virus, which can enable on-site diagnosis of infection. Medical validation for the device is performed through biostatistical analysis using the ROC (Receiver Operating Characteristic) method. The predictive accuracy of the device is 63.3% and 60.6% for reflection and phase, respectively. The device has advantages of low cost, low size and weight and rapid response. It does need a trained technician to operate it since a software program operates automatically. The device can be used at ports’ quarantine units, hospitals, etc.
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spelling pubmed-85881522021-11-13 Rapid Detection of Coronavirus (COVID-19) Using Microwave Immunosensor Cavity Resonator Elsheakh, Dalia M. Ahmed, Mohamed I. Elashry, Gomaa M. Moghannem, Saad M. Elsadek, Hala A. Elmazny, Waleed N. Alieldin, Nelly H. Abdallah, Esmat A. Sensors (Basel) Article This paper presents a rapid diagnostic device for the detection of the pandemic coronavirus (COVID-19) using a micro-immunosensor cavity resonator. Coronavirus has been declared an international public health crisis, so it is important to design quick diagnostic methods for the detection of infected cases, especially in rural areas, to limit the spread of the virus. Herein, a proof-of-concept is presented for a portable laboratory device for the detection of the SARS-CoV-2 virus using electromagnetic biosensors. This device is a microwave cavity resonator (MCR) composed of a sensor operating at industrial, scientific and medical (ISM) 2.45 GHz inserted in 3D housing. The changes of electrical properties of measured serum samples after passing the sensor surface are presented. The three change parameters of the sensor are resonating frequency value, amplitude and phase of the reflection coefficient |S(11)|. This immune-sensor offers a portable, rapid and accurate diagnostic method for the SARS-CoV-2 virus, which can enable on-site diagnosis of infection. Medical validation for the device is performed through biostatistical analysis using the ROC (Receiver Operating Characteristic) method. The predictive accuracy of the device is 63.3% and 60.6% for reflection and phase, respectively. The device has advantages of low cost, low size and weight and rapid response. It does need a trained technician to operate it since a software program operates automatically. The device can be used at ports’ quarantine units, hospitals, etc. MDPI 2021-10-23 /pmc/articles/PMC8588152/ /pubmed/34770328 http://dx.doi.org/10.3390/s21217021 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Elsheakh, Dalia M.
Ahmed, Mohamed I.
Elashry, Gomaa M.
Moghannem, Saad M.
Elsadek, Hala A.
Elmazny, Waleed N.
Alieldin, Nelly H.
Abdallah, Esmat A.
Rapid Detection of Coronavirus (COVID-19) Using Microwave Immunosensor Cavity Resonator
title Rapid Detection of Coronavirus (COVID-19) Using Microwave Immunosensor Cavity Resonator
title_full Rapid Detection of Coronavirus (COVID-19) Using Microwave Immunosensor Cavity Resonator
title_fullStr Rapid Detection of Coronavirus (COVID-19) Using Microwave Immunosensor Cavity Resonator
title_full_unstemmed Rapid Detection of Coronavirus (COVID-19) Using Microwave Immunosensor Cavity Resonator
title_short Rapid Detection of Coronavirus (COVID-19) Using Microwave Immunosensor Cavity Resonator
title_sort rapid detection of coronavirus (covid-19) using microwave immunosensor cavity resonator
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588152/
https://www.ncbi.nlm.nih.gov/pubmed/34770328
http://dx.doi.org/10.3390/s21217021
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