Cargando…

X-ray Structure Determination, Antioxidant Voltammetry Studies of Butein and 2′,4′-Dihydroxy-3,4-dimethoxychalcone. Computational Studies of 4 Structurally Related 2′,4′-diOH Chalcones to Examine Their Antimalarial Activity by Binding to Falcipain-2

Malaria is a huge global health burden with resistance to currently available medicines resulting in the search for newer antimalarial compounds from traditional medicinal plants in malaria-endemic regions. Previous studies on two chalcones, homobutein and 5-prenylbutein, present in E. abyssinica, h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Okoye, Ijeoma, Yu, Sandra, Caruso, Francesco, Rossi, Miriam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588236/ https://www.ncbi.nlm.nih.gov/pubmed/34770920 http://dx.doi.org/10.3390/molecules26216511

Ejemplares similares

Trojan Horse Delivery of 4,4′‐Dimethoxychalcone for Parkinsonian Neuroprotection
por: Zhang, Wenlong, et al.
Publicado: (2021)

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species
por: Carmona-Gutierrez, Didac, et al.
Publicado: (2019)

Microsecond-long simulation reveals the molecular mechanism for the dual inhibition of falcipain-2 and falcipain-3 by antimalarial lead compounds
por: Danazumi, Ammar Usman, et al.
Publicado: (2022)

Structures of Falcipain-2 and Falcipain-3 Bound to Small Molecule Inhibitors: Implications for Substrate Specificity
por: Kerr, Iain D., et al.
Publicado: (2009)

4,4'Dimethoxychalcone: a natural flavonoid that promotes health through autophagy-dependent and -independent effects
por: Zimmermann, Andreas, et al.
Publicado: (2019)

2,4-Dihydroxybenzaldehyde 4-methylthiosemicarbazone
por: Tan, Kong Wai, et al.
Publicado: (2008)

2,4-Dihydroxybenzaldehyde 4-ethylthiosemicarbazone
por: Tan, Kong Wai, et al.
Publicado: (2008)

3,4-dimethoxychalcone novel ultraviolet-A-protection factor in conventional sunscreen cream
por: Fatmasari, Erlina, et al.
Publicado: (2021)

Virtual design of novel Plasmodium falciparum cysteine protease falcipain-2 hybrid lactone–chalcone and isatin–chalcone inhibitors probing the S2 active site pocket
por: Allangba, Koffi N’Guessan Placide Gabin, et al.
Publicado: (2019)

2′,3,4,4′-Tetramethoxychalcone
por: van Tonder, Johannes H., et al.
Publicado: (2010)

(E)-2,4-Dihydroxybenzaldehyde 4-ethylthiosemicarbazone–4,4′-bipyridine–water (4/7/2)
por: Ng, Seik Weng
Publicado: (2009)

Crystal structure and Hirshfeld analysis of 3′-bromo-4-methylchalcone and 3′-cyano-4-methylchalcone
por: Battaglia, Zachary O., et al.
Publicado: (2020)

3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB
por: Chen, Guo, et al.
Publicado: (2019)

(E)-2-(2,4-Dihydroxybenzylideneamino)benzonitrile
por: Liu, Ting
Publicado: (2009)

2,4-Dihydroxy-N′-(4-methoxybenzylidene)benzohydrazide
por: Diao, Yun-Peng, et al.
Publicado: (2008)

4-[(2,4-Dihydroxybenzylidene)ammonio]benzenesulfonate trihydrate
por: Yeap, Chin Sing, et al.
Publicado: (2010)

Methyl 2,4-dihydroxy-5-(4-nitrobenzamido)benzoate
por: Naz, Syeda Sohaila, et al.
Publicado: (2013)

Mechanism of falcipain-2 inhibition by α,β-unsaturated benzo[1,4]diazepin-2-one methyl ester
por: Grazioso, Giovanni, et al.
Publicado: (2012)

Syntheses, Structures, and Properties of Coordination Polymers with 2,5-Dihydroxy-1,4-Benzoquinone and 4,4′-Bipyridyl Synthesized by In Situ Hydrolysis Method
por: Yamazui, Daiki, et al.
Publicado: (2022)

2′,3,4,4′,5-Pentamethoxychalcone
por: van Tonder, Johannes H., et al.
Publicado: (2010)

Antifungal Activity of 2-Hydroxy 4,4'6'Trimethoxy Chalcone
por: Mishra, P. K., et al.
Publicado: (2007)

Structure-Function of Falcipains: Malarial Cysteine Proteases
por: Pandey, Kailash C., et al.
Publicado: (2012)

Hemoglobin Cleavage Site-Specificity of the Plasmodium falciparum Cysteine Proteases Falcipain-2 and Falcipain-3
por: Subramanian, Shoba, et al.
Publicado: (2009)

Crystal structure of 2-bromo-1,4-dihydroxy-9,10-anthraquinone
por: Furukawa, Wataru, et al.
Publicado: (2014)

Crystal structure of 1-(2,4-dihydroxy-6-methylphenyl)ethanone
por: Prabpai, Samran, et al.
Publicado: (2015)

3,4-dimethoxychalcone induces autophagy and reduces neointimal hyperplasia and aortic lesions in mouse models of atherosclerosis
por: Cerrato, Giulia, et al.
Publicado: (2023)

Antimalarial Activity of 4-Metoxychalcones: Docking Studies as Falcipain/Plasmepsin Inhibitors, ADMET and Lipophilic Efficiency Analysis to Identify a Putative Oral Lead Candidate
por: de Oliveira, Michael Eder, et al.
Publicado: (2013)

Synthesis and study the analgesic and anti-inflammatory effects of rigid benzofurane 3, 4 dihydroxy chalcon (DHC) in mice
por: Heidari, Mahmoud Reza, et al.
Publicado: (2010)

Identification of Potential Antimalarial Drug Candidates Targeting Falcipain-2 Protein of Malaria Parasite—A Computational Strategy
por: Nema, Shrikant, et al.
Publicado: (2022)

The Effects of 2′-Hydroxy-3,6′-Dimethoxychalcone on Melanogenesis and Inflammation
por: Bae, Sungmin, et al.
Publicado: (2023)

1,4-Dihydroxyquinoxaline-2,3(1H,4H)-dione
por: Abu-El-Halawah, Rajab, et al.
Publicado: (2008)

3,5-Dihydroxy-2-methyl-4H-pyran-4-one
por: Dong, Cheng-Ming, et al.
Publicado: (2008)

7,7′-Dihydroxy-4,4′-dimethyl-3,4-dihydro-2H,2′H-4,6′-bichromene-2,2′-dione
por: Pereira Silva, P. S., et al.
Publicado: (2010)

2,4-Dihydroxy-N′-(2-hydroxy-4-methoxybenzylidene)benzohydrazide
por: Han, You-Yue, et al.
Publicado: (2010)

2,5-Dihydroxybenzaldehyde 4-methylthiosemicarbazone
por: Tan, Kong Wai, et al.
Publicado: (2008)

Target-Based Virtual Screening of Natural Compounds Identifies a Potent Antimalarial With Selective Falcipain-2 Inhibitory Activity
por: Uddin, Amad, et al.
Publicado: (2022)

2-(3,4-Dihydro-4-Oxothieno[2,3-d]pyrimidin-2-ylthio) Acetamides as a New Class of Falcipain-2 Inhibitors. 3. Design, Synthesis and Biological Evaluation
por: Zhu, Jin, et al.
Publicado: (2009)

1-(3,4-Dihydroxyphenyl)-2-(4-fluorophenyl)ethanone
por: Song, Xiao-Qing
Publicado: (2008)

4,6-Dihydroxy-4,6-dimethyl-1,3-diazinane-2-thione
por: Aliyeva, Khatira N., et al.
Publicado: (2011)

1-(3,4-Dihydroxyphenyl)-2-(4-hydroxyphenyl)ethanone
por: Xiao, Zhu-Ping, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_q98b6q0nqnn8heumqchpsj06i8