Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease

The pathogenesis of Alzheimer’s disease (AD) is still unclear, and presently there is no cure for the disease that can be used for its treatment or to stop its progression. Here, we investigated the therapeutic potential of ramalin (isolated from the Antarctic lichen, Ramalina terebrata), which exhi...

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Autores principales: Kim, Tai Kyoung, Hong, Ju-Mi, Kim, Kyung Hee, Han, Se Jong, Kim, Il-Chan, Oh, Hyuncheol, Yim, Joung Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588271/
https://www.ncbi.nlm.nih.gov/pubmed/34770857
http://dx.doi.org/10.3390/molecules26216445
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author Kim, Tai Kyoung
Hong, Ju-Mi
Kim, Kyung Hee
Han, Se Jong
Kim, Il-Chan
Oh, Hyuncheol
Yim, Joung Han
author_facet Kim, Tai Kyoung
Hong, Ju-Mi
Kim, Kyung Hee
Han, Se Jong
Kim, Il-Chan
Oh, Hyuncheol
Yim, Joung Han
author_sort Kim, Tai Kyoung
collection PubMed
description The pathogenesis of Alzheimer’s disease (AD) is still unclear, and presently there is no cure for the disease that can be used for its treatment or to stop its progression. Here, we investigated the therapeutic potential of ramalin (isolated from the Antarctic lichen, Ramalina terebrata), which exhibits various physiological activities, in AD. Specifically, derivatives were synthesized based on the structure of ramalin, which has a strong antioxidant effect, BACE-1 inhibition activity, and anti-inflammatory effects. Therefore, ramalin and its derivatives exhibit activity against multiple targets associated with AD and can serve as potential therapeutic agents for the disease.
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spelling pubmed-85882712021-11-13 Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease Kim, Tai Kyoung Hong, Ju-Mi Kim, Kyung Hee Han, Se Jong Kim, Il-Chan Oh, Hyuncheol Yim, Joung Han Molecules Article The pathogenesis of Alzheimer’s disease (AD) is still unclear, and presently there is no cure for the disease that can be used for its treatment or to stop its progression. Here, we investigated the therapeutic potential of ramalin (isolated from the Antarctic lichen, Ramalina terebrata), which exhibits various physiological activities, in AD. Specifically, derivatives were synthesized based on the structure of ramalin, which has a strong antioxidant effect, BACE-1 inhibition activity, and anti-inflammatory effects. Therefore, ramalin and its derivatives exhibit activity against multiple targets associated with AD and can serve as potential therapeutic agents for the disease. MDPI 2021-10-26 /pmc/articles/PMC8588271/ /pubmed/34770857 http://dx.doi.org/10.3390/molecules26216445 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Tai Kyoung
Hong, Ju-Mi
Kim, Kyung Hee
Han, Se Jong
Kim, Il-Chan
Oh, Hyuncheol
Yim, Joung Han
Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease
title Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease
title_full Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease
title_fullStr Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease
title_full_unstemmed Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease
title_short Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease
title_sort potential of ramalin and its derivatives for the treatment of alzheimer’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588271/
https://www.ncbi.nlm.nih.gov/pubmed/34770857
http://dx.doi.org/10.3390/molecules26216445
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