Cargando…
Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development
Plasmon waveguide resonance (PWR) is a variant of surface plasmon resonance (SPR) that was invented about two decades ago at the University of Arizona. In addition to the characterization of the kinetics and affinity of molecular interactions, PWR possesses several advantages relative to SPR, namely...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588475/ https://www.ncbi.nlm.nih.gov/pubmed/34770851 http://dx.doi.org/10.3390/molecules26216442 |
_version_ | 1784598469865897984 |
---|---|
author | Rascol, Estelle Villette, Sandrine Harté, Etienne Alves, Isabel D. |
author_facet | Rascol, Estelle Villette, Sandrine Harté, Etienne Alves, Isabel D. |
author_sort | Rascol, Estelle |
collection | PubMed |
description | Plasmon waveguide resonance (PWR) is a variant of surface plasmon resonance (SPR) that was invented about two decades ago at the University of Arizona. In addition to the characterization of the kinetics and affinity of molecular interactions, PWR possesses several advantages relative to SPR, namely, the ability to monitor both mass and structural changes. PWR allows anisotropy information to be obtained and is ideal for the investigation of molecular interactions occurring in anisotropic-oriented thin films. In this review, we will revisit main PWR applications, aiming at characterizing molecular interactions occurring (1) at lipid membranes deposited in the sensor and (2) in chemically modified sensors. Among the most widely used applications is the investigation of G-protein coupled receptor (GPCR) ligand activation and the study of the lipid environment’s impact on this process. Pioneering PWR studies on GPCRs were carried out thanks to the strong and effective collaboration between two laboratories in the University of Arizona leaded by Dr. Gordon Tollin and Dr. Victor J. Hruby. This review provides an overview of the main applications of PWR and provides a historical perspective on the development of instruments since the first prototype and continuous technological improvements to ongoing and future developments, aiming at broadening the information obtained and expanding the application portfolio. |
format | Online Article Text |
id | pubmed-8588475 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85884752021-11-13 Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development Rascol, Estelle Villette, Sandrine Harté, Etienne Alves, Isabel D. Molecules Review Plasmon waveguide resonance (PWR) is a variant of surface plasmon resonance (SPR) that was invented about two decades ago at the University of Arizona. In addition to the characterization of the kinetics and affinity of molecular interactions, PWR possesses several advantages relative to SPR, namely, the ability to monitor both mass and structural changes. PWR allows anisotropy information to be obtained and is ideal for the investigation of molecular interactions occurring in anisotropic-oriented thin films. In this review, we will revisit main PWR applications, aiming at characterizing molecular interactions occurring (1) at lipid membranes deposited in the sensor and (2) in chemically modified sensors. Among the most widely used applications is the investigation of G-protein coupled receptor (GPCR) ligand activation and the study of the lipid environment’s impact on this process. Pioneering PWR studies on GPCRs were carried out thanks to the strong and effective collaboration between two laboratories in the University of Arizona leaded by Dr. Gordon Tollin and Dr. Victor J. Hruby. This review provides an overview of the main applications of PWR and provides a historical perspective on the development of instruments since the first prototype and continuous technological improvements to ongoing and future developments, aiming at broadening the information obtained and expanding the application portfolio. MDPI 2021-10-26 /pmc/articles/PMC8588475/ /pubmed/34770851 http://dx.doi.org/10.3390/molecules26216442 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rascol, Estelle Villette, Sandrine Harté, Etienne Alves, Isabel D. Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development |
title | Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development |
title_full | Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development |
title_fullStr | Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development |
title_full_unstemmed | Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development |
title_short | Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development |
title_sort | plasmon waveguide resonance: principles, applications and historical perspectives on instrument development |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588475/ https://www.ncbi.nlm.nih.gov/pubmed/34770851 http://dx.doi.org/10.3390/molecules26216442 |
work_keys_str_mv | AT rascolestelle plasmonwaveguideresonanceprinciplesapplicationsandhistoricalperspectivesoninstrumentdevelopment AT villettesandrine plasmonwaveguideresonanceprinciplesapplicationsandhistoricalperspectivesoninstrumentdevelopment AT harteetienne plasmonwaveguideresonanceprinciplesapplicationsandhistoricalperspectivesoninstrumentdevelopment AT alvesisabeld plasmonwaveguideresonanceprinciplesapplicationsandhistoricalperspectivesoninstrumentdevelopment |