Integration of adeno-associated virus (AAV) into the genomes of most Thai and Mongolian liver cancer patients does not induce oncogenesis

BACKGROUND: Engineered versions of adeno-associated virus (AAV) are commonly used in gene therapy but evidence revealing a potential oncogenic role of natural AAV in hepatocellular carcinoma (HCC) has raised concerns. The frequency of potentially oncogenic integrations has been reported in only a fe...

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Detalles Bibliográficos
Autores principales: Schäffer, Alejandro A., Dominguez, Dana A., Chapman, Lesley M., Gertz, E. Michael, Budhu, Anuradha, Forgues, Marshonna, Chaisaingmongkol, Jittiporn, Rabibhadana, Siritida, Pupacdi, Benjarath, Wu, Xiaolin, Bayarsaikhan, Enkhjargal, Harris, Curtis C., Ruchirawat, Mathuros, Ruppin, Eytan, Wang, Xin Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588581/
https://www.ncbi.nlm.nih.gov/pubmed/34763675
http://dx.doi.org/10.1186/s12864-021-08098-9

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