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Development and Application of Patient-Derived Cancer Organoidsin Clinical Management of Gastrointestinal Cancer: A State-of-the-Art Review

Human gastrointestinal cancer (e.g., gastric cancer and colorectal cancer) has been a leading cause of cancer-related deaths worldwide and has imposed a great threat to the public health. Although early-stage gastrointestinal cancer can be effectively treated by surgery, followed by postoperative ch...

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Autores principales: Zhang, Ruobing, Guo, Tiantian, Ji, Lulin, Yin, Yirui, Feng, Shuitu, Lu, Weihong, Zhang, Fei, Zhu, Maoshu, Liu, Shugang, Jiang, Jinhua, Zeng, Fanwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588806/
https://www.ncbi.nlm.nih.gov/pubmed/34778032
http://dx.doi.org/10.3389/fonc.2021.716339
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author Zhang, Ruobing
Guo, Tiantian
Ji, Lulin
Yin, Yirui
Feng, Shuitu
Lu, Weihong
Zhang, Fei
Zhu, Maoshu
Liu, Shugang
Jiang, Jinhua
Zeng, Fanwei
author_facet Zhang, Ruobing
Guo, Tiantian
Ji, Lulin
Yin, Yirui
Feng, Shuitu
Lu, Weihong
Zhang, Fei
Zhu, Maoshu
Liu, Shugang
Jiang, Jinhua
Zeng, Fanwei
author_sort Zhang, Ruobing
collection PubMed
description Human gastrointestinal cancer (e.g., gastric cancer and colorectal cancer) has been a leading cause of cancer-related deaths worldwide and has imposed a great threat to the public health. Although early-stage gastrointestinal cancer can be effectively treated by surgery, followed by postoperative chemotherapy, patients with advanced gastrointestinal cancer often exhibit poor prognosis and cancer relapse due to the absence of effective personalized treatment strategies. Patient-derived cancer organoid technology has been rapidly developed in recent years, and its emergence has opened up an unprecedented approach to model human cancers in vitro. Patient-derived cancer organoids involve the ex vivo culture of fragments of freshly resected human tumors that retain the histological features of original tumors. This review thoroughly discussed the evolutionary process of human gastrointestinal organoids cultured since 2009, and highlighted the potentials of patient-derived cancer organoids in clinical management of gastrointestinal cancer in terms of advances achieved in cancer modelling compared with conventional modelling methods, high-throughput drug screening, and development of personalized treatment selection. Additionally, the current limitations of patient-derived cancer organoids and the potential solutions to overcome these problems were summarized.
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spelling pubmed-85888062021-11-13 Development and Application of Patient-Derived Cancer Organoidsin Clinical Management of Gastrointestinal Cancer: A State-of-the-Art Review Zhang, Ruobing Guo, Tiantian Ji, Lulin Yin, Yirui Feng, Shuitu Lu, Weihong Zhang, Fei Zhu, Maoshu Liu, Shugang Jiang, Jinhua Zeng, Fanwei Front Oncol Oncology Human gastrointestinal cancer (e.g., gastric cancer and colorectal cancer) has been a leading cause of cancer-related deaths worldwide and has imposed a great threat to the public health. Although early-stage gastrointestinal cancer can be effectively treated by surgery, followed by postoperative chemotherapy, patients with advanced gastrointestinal cancer often exhibit poor prognosis and cancer relapse due to the absence of effective personalized treatment strategies. Patient-derived cancer organoid technology has been rapidly developed in recent years, and its emergence has opened up an unprecedented approach to model human cancers in vitro. Patient-derived cancer organoids involve the ex vivo culture of fragments of freshly resected human tumors that retain the histological features of original tumors. This review thoroughly discussed the evolutionary process of human gastrointestinal organoids cultured since 2009, and highlighted the potentials of patient-derived cancer organoids in clinical management of gastrointestinal cancer in terms of advances achieved in cancer modelling compared with conventional modelling methods, high-throughput drug screening, and development of personalized treatment selection. Additionally, the current limitations of patient-derived cancer organoids and the potential solutions to overcome these problems were summarized. Frontiers Media S.A. 2021-10-29 /pmc/articles/PMC8588806/ /pubmed/34778032 http://dx.doi.org/10.3389/fonc.2021.716339 Text en Copyright © 2021 Zhang, Guo, Ji, Yin, Feng, Lu, Zhang, Zhu, Liu, Jiang and Zeng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhang, Ruobing
Guo, Tiantian
Ji, Lulin
Yin, Yirui
Feng, Shuitu
Lu, Weihong
Zhang, Fei
Zhu, Maoshu
Liu, Shugang
Jiang, Jinhua
Zeng, Fanwei
Development and Application of Patient-Derived Cancer Organoidsin Clinical Management of Gastrointestinal Cancer: A State-of-the-Art Review
title Development and Application of Patient-Derived Cancer Organoidsin Clinical Management of Gastrointestinal Cancer: A State-of-the-Art Review
title_full Development and Application of Patient-Derived Cancer Organoidsin Clinical Management of Gastrointestinal Cancer: A State-of-the-Art Review
title_fullStr Development and Application of Patient-Derived Cancer Organoidsin Clinical Management of Gastrointestinal Cancer: A State-of-the-Art Review
title_full_unstemmed Development and Application of Patient-Derived Cancer Organoidsin Clinical Management of Gastrointestinal Cancer: A State-of-the-Art Review
title_short Development and Application of Patient-Derived Cancer Organoidsin Clinical Management of Gastrointestinal Cancer: A State-of-the-Art Review
title_sort development and application of patient-derived cancer organoidsin clinical management of gastrointestinal cancer: a state-of-the-art review
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588806/
https://www.ncbi.nlm.nih.gov/pubmed/34778032
http://dx.doi.org/10.3389/fonc.2021.716339
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