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Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?: Assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin

Skin permeation is an integral part of penetration of topical therapeutics. Zero order in addition to Higuchi permeation kinetic is usually preferred in topical drug delivery cargo. Penetration of therapeutic entities through epidermal barrier is a major challenge for scientific fraternity. Furtherm...

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Autores principales: Iyer, Akshaya, Jyothi, Vaskuri G. S. Sainaga, Agrawal, Aashruti, Khatri, Dharmendra Kumar, Srivastava, Saurabh, Singh, Shashi Bala, Madan, Jitender
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588922/
https://www.ncbi.nlm.nih.gov/pubmed/34820308
http://dx.doi.org/10.4103/japtr.japtr_82_21
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author Iyer, Akshaya
Jyothi, Vaskuri G. S. Sainaga
Agrawal, Aashruti
Khatri, Dharmendra Kumar
Srivastava, Saurabh
Singh, Shashi Bala
Madan, Jitender
author_facet Iyer, Akshaya
Jyothi, Vaskuri G. S. Sainaga
Agrawal, Aashruti
Khatri, Dharmendra Kumar
Srivastava, Saurabh
Singh, Shashi Bala
Madan, Jitender
author_sort Iyer, Akshaya
collection PubMed
description Skin permeation is an integral part of penetration of topical therapeutics. Zero order in addition to Higuchi permeation kinetic is usually preferred in topical drug delivery cargo. Penetration of therapeutic entities through epidermal barrier is a major challenge for scientific fraternity. Furthermore, penetration of therapeutic entities determines the transportation and ultimately therapeutic efficacy of topical dermal dosage forms. Apart from experimentation models, mathematical equations, in silico docking, molecular dynamics (MDs), and artificial neural network (Neural) techniques are being used to assess free energies and prediction of electrostatic attractions in order to predict the permeation phenomena of therapeutic entities. Therefore, in the present review, we have summarized the significance of kinetic equations, in silico docking, MDs, and ANN in assessing and predicting the penetration behavior of topical therapeutics through dermal dosage form. In addition, the role of chitosan biomacromolecule in modulating permeation of topical therapeutics in skin has also been illustrated using computational techniques.
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spelling pubmed-85889222021-11-23 Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?: Assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin Iyer, Akshaya Jyothi, Vaskuri G. S. Sainaga Agrawal, Aashruti Khatri, Dharmendra Kumar Srivastava, Saurabh Singh, Shashi Bala Madan, Jitender J Adv Pharm Technol Res Review Article Skin permeation is an integral part of penetration of topical therapeutics. Zero order in addition to Higuchi permeation kinetic is usually preferred in topical drug delivery cargo. Penetration of therapeutic entities through epidermal barrier is a major challenge for scientific fraternity. Furthermore, penetration of therapeutic entities determines the transportation and ultimately therapeutic efficacy of topical dermal dosage forms. Apart from experimentation models, mathematical equations, in silico docking, molecular dynamics (MDs), and artificial neural network (Neural) techniques are being used to assess free energies and prediction of electrostatic attractions in order to predict the permeation phenomena of therapeutic entities. Therefore, in the present review, we have summarized the significance of kinetic equations, in silico docking, MDs, and ANN in assessing and predicting the penetration behavior of topical therapeutics through dermal dosage form. In addition, the role of chitosan biomacromolecule in modulating permeation of topical therapeutics in skin has also been illustrated using computational techniques. Wolters Kluwer - Medknow 2021 2021-10-20 /pmc/articles/PMC8588922/ /pubmed/34820308 http://dx.doi.org/10.4103/japtr.japtr_82_21 Text en Copyright: © 2021 Journal of Advanced Pharmaceutical Technology & Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Iyer, Akshaya
Jyothi, Vaskuri G. S. Sainaga
Agrawal, Aashruti
Khatri, Dharmendra Kumar
Srivastava, Saurabh
Singh, Shashi Bala
Madan, Jitender
Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?: Assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin
title Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?: Assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin
title_full Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?: Assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin
title_fullStr Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?: Assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin
title_full_unstemmed Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?: Assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin
title_short Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?: Assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin
title_sort does skin permeation kinetics influence efficacy of topical dermal drug delivery system?: assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588922/
https://www.ncbi.nlm.nih.gov/pubmed/34820308
http://dx.doi.org/10.4103/japtr.japtr_82_21
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