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Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy

BACKGROUND/AIMS: Postoperative abdominal fluid collection (PAFC) is a frequent complication of pancreatobiliary cancer surgery. The effects of the existence and duration of PAFC are not well known. This study aimed to assess the effects of PAFC on patient prognosis after surgery for pancreatobiliary...

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Autores principales: Kim, Young Jung, Cheon, Young Koog, Lee, Tae Yoon, Chang, Seong-Hwan, Yu, Mi-Hye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Internal Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588986/
https://www.ncbi.nlm.nih.gov/pubmed/34147058
http://dx.doi.org/10.3904/kjim.2021.056
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author Kim, Young Jung
Cheon, Young Koog
Lee, Tae Yoon
Chang, Seong-Hwan
Yu, Mi-Hye
author_facet Kim, Young Jung
Cheon, Young Koog
Lee, Tae Yoon
Chang, Seong-Hwan
Yu, Mi-Hye
author_sort Kim, Young Jung
collection PubMed
description BACKGROUND/AIMS: Postoperative abdominal fluid collection (PAFC) is a frequent complication of pancreatobiliary cancer surgery. The effects of the existence and duration of PAFC are not well known. This study aimed to assess the effects of PAFC on patient prognosis after surgery for pancreatobiliary adenocarcinoma and the association of longstanding PAFC with the recurrence of pancreatic cancer. METHODS: We retrospectively analyzed the data of 194 consecutive patients with pancreatobiliary adenocarcinoma who underwent curative operations from August 2005 to December 2019. The presence of PAFC was assessed using computed tomography within a week of surgery; PAFC lasting > 4 weeks was defined as longstanding PAFC. RESULTS: Among 194 patients, PAFC occurred in 165 (85.1%), and 74 of these had longstanding PAFC. The recurrence rate of pancreatobiliary adenocarcinoma was significantly higher in patients with longstanding PAFC than in patients with non-longstanding PAFC (p = 0.025). Recurrence was also significantly associated with high T stage (T3, T4; p = 0.040), lymph node involvement (p < 0.001), perineural invasion (p < 0.006), and non-receipt of adjuvant chemotherapy (p = 0.025). Longstanding PAFC was significantly associated with the recurrence of pancreatic adenocarcinoma (p = 0.016). However, cancer-specific survival was related to neither the presence nor the duration of PAFC. CONCLUSIONS: The presence of longstanding PAFC was associated with the recurrence of pancreatic adenocarcinoma. However, a larger prospective study is necessary to confirm the findings.
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spelling pubmed-85889862021-11-18 Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy Kim, Young Jung Cheon, Young Koog Lee, Tae Yoon Chang, Seong-Hwan Yu, Mi-Hye Korean J Intern Med Original Article BACKGROUND/AIMS: Postoperative abdominal fluid collection (PAFC) is a frequent complication of pancreatobiliary cancer surgery. The effects of the existence and duration of PAFC are not well known. This study aimed to assess the effects of PAFC on patient prognosis after surgery for pancreatobiliary adenocarcinoma and the association of longstanding PAFC with the recurrence of pancreatic cancer. METHODS: We retrospectively analyzed the data of 194 consecutive patients with pancreatobiliary adenocarcinoma who underwent curative operations from August 2005 to December 2019. The presence of PAFC was assessed using computed tomography within a week of surgery; PAFC lasting > 4 weeks was defined as longstanding PAFC. RESULTS: Among 194 patients, PAFC occurred in 165 (85.1%), and 74 of these had longstanding PAFC. The recurrence rate of pancreatobiliary adenocarcinoma was significantly higher in patients with longstanding PAFC than in patients with non-longstanding PAFC (p = 0.025). Recurrence was also significantly associated with high T stage (T3, T4; p = 0.040), lymph node involvement (p < 0.001), perineural invasion (p < 0.006), and non-receipt of adjuvant chemotherapy (p = 0.025). Longstanding PAFC was significantly associated with the recurrence of pancreatic adenocarcinoma (p = 0.016). However, cancer-specific survival was related to neither the presence nor the duration of PAFC. CONCLUSIONS: The presence of longstanding PAFC was associated with the recurrence of pancreatic adenocarcinoma. However, a larger prospective study is necessary to confirm the findings. Korean Association of Internal Medicine 2021-11 2021-06-21 /pmc/articles/PMC8588986/ /pubmed/34147058 http://dx.doi.org/10.3904/kjim.2021.056 Text en Copyright © 2021 The Korean Association of Internal Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Young Jung
Cheon, Young Koog
Lee, Tae Yoon
Chang, Seong-Hwan
Yu, Mi-Hye
Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
title Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
title_full Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
title_fullStr Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
title_full_unstemmed Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
title_short Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
title_sort longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588986/
https://www.ncbi.nlm.nih.gov/pubmed/34147058
http://dx.doi.org/10.3904/kjim.2021.056
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