Epstein–Barr virus (EBV) deletions as biomarkers of response to treatment of chronic active EBV

Chronic active Epstein–Barr virus (CAEBV) disease is a rare condition characterised by persistent EBV infection in previously healthy individuals. Defective EBV genomes were found in East Asian patients with CAEBV. In the present study, we sequenced 14 blood EBV samples from three UK patients with C...

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Detalles Bibliográficos
Autores principales: Venturini, Cristina, Houldcroft, Charlotte J., Lazareva, Arina, Wegner, Fanny, Morfopoulou, Sofia, Amrolia, Persis J., Golwala, Zainab, Rao, Anupama, Marks, Stephen D., Simmonds, Jacob, Yoshikawa, Tetsushi, Farrell, Paul J., Cohen, Jeffrey I., Worth, Austen J., Breuer, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Haematological malignancy–Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589012/
https://www.ncbi.nlm.nih.gov/pubmed/34431085
http://dx.doi.org/10.1111/bjh.17790
Descripción
Sumario:Chronic active Epstein–Barr virus (CAEBV) disease is a rare condition characterised by persistent EBV infection in previously healthy individuals. Defective EBV genomes were found in East Asian patients with CAEBV. In the present study, we sequenced 14 blood EBV samples from three UK patients with CAEBV, comparing the results with saliva CAEBV samples and other conditions. We observed EBV deletions in blood, some of which may disrupt viral replication, but not saliva in CAEBV. Deletions were lost overtime after successful treatment. These findings are compatible with CAEBV being associated with the evolution and persistence of EBV(+) haematological clones that are lost on successful treatment.

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