Protein Aggregation Is an Early Manifestation of Phospholamban p.(Arg14del)–Related Cardiomyopathy: Development of PLN-R14del–Related Cardiomyopathy

The p.(Arg14del) pathogenic variant (R14del) of the PLN (phospholamban) gene is a prevalent cause of cardiomyopathy with heart failure. The exact underlying pathophysiology is unknown, and a suitable therapy is unavailable. We aim to identify molecular perturbations underlying this cardiomyopathy in...

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Detalles Bibliográficos
Autores principales: Eijgenraam, Tim R., Boogerd, Cornelis J., Stege, Nienke M., Oliveira Nunes Teixeira, Vivian, Dokter, Martin M., Schmidt, Lukas E., Yin, Xiaoke, Theofilatos, Konstantinos, Mayr, Manuel, van der Meer, Peter, van Rooij, Eva, van der Velden, Jolanda, Silljé, Herman H.W., de Boer, Rudolf A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589082/
https://www.ncbi.nlm.nih.gov/pubmed/34587756
http://dx.doi.org/10.1161/CIRCHEARTFAILURE.121.008532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589082/
https://www.ncbi.nlm.nih.gov/pubmed/34587756
http://dx.doi.org/10.1161/CIRCHEARTFAILURE.121.008532

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