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The impact of infection-derived immunity on disease dynamics
When modeling infectious diseases, it is common to assume that infection-derived immunity is either (1) non-existent or (2) perfect and lifelong. However there are many diseases in which infection-derived immunity is known to be present but imperfect. There are various ways in which infection-derive...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589100/ https://www.ncbi.nlm.nih.gov/pubmed/34773173 http://dx.doi.org/10.1007/s00285-021-01681-4 |
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author | Le, Adam King, Aaron A. Magpantay, Felicia Maria G. Mesbahi, Afshin Rohani, Pejman |
author_facet | Le, Adam King, Aaron A. Magpantay, Felicia Maria G. Mesbahi, Afshin Rohani, Pejman |
author_sort | Le, Adam |
collection | PubMed |
description | When modeling infectious diseases, it is common to assume that infection-derived immunity is either (1) non-existent or (2) perfect and lifelong. However there are many diseases in which infection-derived immunity is known to be present but imperfect. There are various ways in which infection-derived immunity can fail, which can ultimately impact the probability that an individual be reinfected by the same pathogen, as well as the long-run population-level prevalence of the pathogen. Here we discuss seven different models of imperfect infection-derived immunity, including waning, leaky and all-or-nothing immunity. For each model we derive the probability that an infected individual becomes reinfected during their lifetime, given that the system is at endemic equilibrium. This can be thought of as the impact that each of these infection-derived immunity failures have on reinfection. This measure is useful because it provides us with a way to compare different modes of failure of infection-derived immunity. |
format | Online Article Text |
id | pubmed-8589100 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-85891002021-11-15 The impact of infection-derived immunity on disease dynamics Le, Adam King, Aaron A. Magpantay, Felicia Maria G. Mesbahi, Afshin Rohani, Pejman J Math Biol Article When modeling infectious diseases, it is common to assume that infection-derived immunity is either (1) non-existent or (2) perfect and lifelong. However there are many diseases in which infection-derived immunity is known to be present but imperfect. There are various ways in which infection-derived immunity can fail, which can ultimately impact the probability that an individual be reinfected by the same pathogen, as well as the long-run population-level prevalence of the pathogen. Here we discuss seven different models of imperfect infection-derived immunity, including waning, leaky and all-or-nothing immunity. For each model we derive the probability that an infected individual becomes reinfected during their lifetime, given that the system is at endemic equilibrium. This can be thought of as the impact that each of these infection-derived immunity failures have on reinfection. This measure is useful because it provides us with a way to compare different modes of failure of infection-derived immunity. Springer Berlin Heidelberg 2021-11-12 2021 /pmc/articles/PMC8589100/ /pubmed/34773173 http://dx.doi.org/10.1007/s00285-021-01681-4 Text en © Crown 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Le, Adam King, Aaron A. Magpantay, Felicia Maria G. Mesbahi, Afshin Rohani, Pejman The impact of infection-derived immunity on disease dynamics |
title | The impact of infection-derived immunity on disease dynamics |
title_full | The impact of infection-derived immunity on disease dynamics |
title_fullStr | The impact of infection-derived immunity on disease dynamics |
title_full_unstemmed | The impact of infection-derived immunity on disease dynamics |
title_short | The impact of infection-derived immunity on disease dynamics |
title_sort | impact of infection-derived immunity on disease dynamics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589100/ https://www.ncbi.nlm.nih.gov/pubmed/34773173 http://dx.doi.org/10.1007/s00285-021-01681-4 |
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