Cargando…

Long-Term Release of Dexamethasone With a Polycaprolactone-Coated Electrode Alleviates Fibrosis in Cochlear Implantation

Cochlear implantation (CI) is the major treatment for severe sensorineural hearing loss. However, the fibrotic tissue forming around the electrodes reduces the treatment effectiveness of CI. Dexamethasone (DEX) is usually applied routinely in perioperative treatment of cochlear implantation (CI), bu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Dongxiu, Luo, Yanjing, Pan, Jing, Chen, Anning, Ma, Dong, Xu, Muqing, Tang, Jie, Zhang, Hongzheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589109/ https://www.ncbi.nlm.nih.gov/pubmed/34778254 http://dx.doi.org/10.3389/fcell.2021.740576

Ejemplares similares

Preparation, characterization, and in vitro/vivo evaluation of dexamethasone/poly(ε-caprolactone)-based electrode coatings for cochlear implants
por: Luo, Yanjing, et al.
Publicado: (2021)

Electrical stimulation of cochlear implant promotes activation of macrophages and fibroblasts under inflammation
por: Zhang, Dingling, et al.
Publicado: (2023)

Gpr125 Marks Distinct Cochlear Cell Types and Is Dispensable for Cochlear Development and Hearing
por: Sun, Haiying, et al.
Publicado: (2021)

A Neurophysiological Study of Musical Pitch Identification in Mandarin-Speaking Cochlear Implant Users
por: Cai, Jieqing, et al.
Publicado: (2020)

Cochlear Development; New Tools and Approaches
por: Kelley, Matthew W.
Publicado: (2022)

Hesperidin Ameliorates Dexamethasone-Induced Osteoporosis by Inhibiting p53
por: Zhang, Meng, et al.
Publicado: (2022)

Dimensions of a Living Cochlear Hair Bundle
por: Miller, Katharine K., et al.
Publicado: (2021)

Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway
por: Fu, Yuanyuan, et al.
Publicado: (2021)

Dexamethasone-loaded cochlear implants: How to provide a desired “burst release”
por: Qnouch, A., et al.
Publicado: (2021)

Gasdermin E Deletion Attenuates Ureteral Obstruction- and 5/6 Nephrectomy-Induced Renal Fibrosis and Kidney Dysfunction
por: Wu, Mengying, et al.
Publicado: (2021)

The Detrimental and Beneficial Functions of Macrophages After Cochlear Injury
por: Zhang, Yuan, et al.
Publicado: (2021)

The Kinocilia of Cochlear Hair Cells: Structures, Functions, and Diseases
por: Wang, Difei, et al.
Publicado: (2021)

Adiponectin Modified BMSCs Alleviate Heart Fibrosis via Inhibition TGF-beta1/Smad in Diabetic Rats
por: Meng, Ke, et al.
Publicado: (2021)

Corrigendum: Adiponectin modified BMSCs alleviate heart fibrosis via inhibition TGF-beta1/smad in diabetic rats
por: Meng, Ke, et al.
Publicado: (2023)

The Rho GTPase Cell Division Cycle 42 Regulates Stereocilia Development in Cochlear Hair Cells
por: Du, Haibo, et al.
Publicado: (2021)

Cochlear Sox2(+) Glial Cells Are Potent Progenitors for Spiral Ganglion Neuron Reprogramming Induced by Small Molecules
por: Chen, Zhen, et al.
Publicado: (2021)

Connexin 30 deletion exacerbates cochlear senescence and age-related hearing loss
por: Paciello, Fabiola, et al.
Publicado: (2022)

Polymer Coatings of Cochlear Implant Electrode Surface – An Option for Improving Electrode-Nerve-Interface by Blocking Fibroblast Overgrowth
por: Hadler, C., et al.
Publicado: (2016)

Applications of Lgr5-Positive Cochlear Progenitors (LCPs) to the Study of Hair Cell Differentiation
por: Lenz, Danielle R., et al.
Publicado: (2019)

Hair Cell Generation in Cochlear Culture Models Mediated by Novel γ-Secretase Inhibitors
por: Erni, Silvia T., et al.
Publicado: (2021)

Local Macrophage-Related Immune Response Is Involved in Cochlear Epithelial Damage in Distinct Gjb2-Related Hereditary Deafness Models
por: Xu, Kai, et al.
Publicado: (2021)

The importance of electrode location in cochlear implantation
por: O'Connell, Brendan P., et al.
Publicado: (2016)

Sirtuin-3 Protects Cochlear Hair Cells Against Noise-Induced Damage via the Superoxide Dismutase 2/Reactive Oxygen Species Signaling Pathway
por: Liang, Wenqi, et al.
Publicado: (2021)

A Nesprin-4/kinesin-1 cargo model for nuclear positioning in cochlear outer hair cells
por: Taiber, Shahar, et al.
Publicado: (2022)

Effects of angiotensin II combined with asparaginase and dexamethasone on the femoral head in mice: A model of steroid-induced femoral head osteonecrosis
por: Liu, Jiahe, et al.
Publicado: (2022)

N-Acetylcysteine Combined With Dexamethasone Treatment Improves Sudden Sensorineural Hearing Loss and Attenuates Hair Cell Death Caused by ROS Stress
por: Bai, Xue, et al.
Publicado: (2021)

Activin/Nodal/TGF-β Pathway Inhibitor Accelerates BMP4-Induced Cochlear Gap Junction Formation During in vitro Differentiation of Embryonic Stem Cells
por: Fukunaga, Ichiro, et al.
Publicado: (2021)

The Effect of Intracochlear and Intratympanic Dexamethasone on Cochlear Implant Impedance
por: Ardıç, Fazıl Necdet, et al.
Publicado: (2023)

Emerging roles of proximal tubular endocytosis in renal fibrosis
por: Chen, Min, et al.
Publicado: (2023)

Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds
por: Abdullah, Turdimuhammad, et al.
Publicado: (2020)

GJB2 Mutations Linked to Hearing Loss Exhibit Differential Trafficking and Functional Defects as Revealed in Cochlear-Relevant Cells
por: Beach, Rianne, et al.
Publicado: (2020)

Non-Canonical Wnt Signaling Regulates Cochlear Outgrowth and Planar Cell Polarity via Gsk3β Inhibition
por: Landin Malt, Andre, et al.
Publicado: (2021)

RIPK3: A New Player in Renal Fibrosis
por: Shi, Ying, et al.
Publicado: (2020)

Coat/Tether Interactions—Exception or Rule?
por: Schröter, Saskia, et al.
Publicado: (2016)

Corrigendum: RIPK3: A New Player in Renal Fibrosis
por: Shi, Ying, et al.
Publicado: (2021)

Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling
por: Huh, Sung-Ho, et al.
Publicado: (2015)

Advances to Electrode Pullback in Cochlear Implant Surgery
por: Todt, Ingo, et al.
Publicado: (2012)

Therapeutic Applications of Mesenchymal Stem Cells in Idiopathic Pulmonary Fibrosis
por: Yang, Shengnan, et al.
Publicado: (2021)

Impedance Changes and Fibrous Tissue Growth after Cochlear Implantation Are Correlated and Can Be Reduced Using a Dexamethasone Eluting Electrode
por: Wilk, Maciej, et al.
Publicado: (2016)

Loss of PDK1 Induces Meiotic Defects in Oocytes From Diabetic Mice
por: Ge, Juan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_f8htvpua6pqdraid5iia22q3j1