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SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice

BACKGROUND AND AIMS: Diabetes is a major risk factor of atherosclerosis and its complications. The loss-of-function mutation E1506K in the sulfonylurea receptor 1 (SUR1-E1506K) induces hyperinsulinemia in infancy, leading to impaired glucose tolerance and increased risk of type 2 diabetes. In this s...

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Detalles Bibliográficos
Autores principales:	Gurzeler, Erika, Ruotsalainen, Anna-Kaisa, Laine, Anssi, Valkama, Teemu, Kettunen, Sanna, Laakso, Markku, Ylä-Herttuala, Seppo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589160/ https://www.ncbi.nlm.nih.gov/pubmed/34767557 http://dx.doi.org/10.1371/journal.pone.0258408

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