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Abnormal Behavior Episodes Associated With Zonisamide in Three Dogs: A Case Report

Psychiatric adverse effect associated with anti-seizure drugs has been well-recognized in human medicine. This case report describes three dogs with presumptive idiopathic epilepsy presented for abnormal behavior episodes. Abnormal behavior episodes included sudden rage and aggression to the family...

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Autores principales: Kanazono, Shinichi, Ukai, Masayasu, Hiramoto, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589241/
https://www.ncbi.nlm.nih.gov/pubmed/34778438
http://dx.doi.org/10.3389/fvets.2021.763822
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author Kanazono, Shinichi
Ukai, Masayasu
Hiramoto, Akira
author_facet Kanazono, Shinichi
Ukai, Masayasu
Hiramoto, Akira
author_sort Kanazono, Shinichi
collection PubMed
description Psychiatric adverse effect associated with anti-seizure drugs has been well-recognized in human medicine. This case report describes three dogs with presumptive idiopathic epilepsy presented for abnormal behavior episodes. Abnormal behavior episodes included sudden rage and aggression to the family members, insomnia, restlessness, and/or constant attention-seeking behavior. MRI study and cerebrospinal fluid analysis in two dogs were unremarkable. The abnormal behavior episodes deteriorated along with gradual dose increment of zonisamide and these episodes almost completely disappeared within 5 days after discontinuation of zonisamide. The exact same episodes relapsed within days after re-administration of zonisamide and disappeared again shortly after discontinuation of zonisamide. Dose adjustments of other anti-seizure medications in case 2 did not result in significant changes in these behavior episodes. Although psychiatric adverse effects including aggressive behavior associated with zonisamide are widely recognized in humans, this is the first report in dogs in the clinical setting.
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spelling pubmed-85892412021-11-13 Abnormal Behavior Episodes Associated With Zonisamide in Three Dogs: A Case Report Kanazono, Shinichi Ukai, Masayasu Hiramoto, Akira Front Vet Sci Veterinary Science Psychiatric adverse effect associated with anti-seizure drugs has been well-recognized in human medicine. This case report describes three dogs with presumptive idiopathic epilepsy presented for abnormal behavior episodes. Abnormal behavior episodes included sudden rage and aggression to the family members, insomnia, restlessness, and/or constant attention-seeking behavior. MRI study and cerebrospinal fluid analysis in two dogs were unremarkable. The abnormal behavior episodes deteriorated along with gradual dose increment of zonisamide and these episodes almost completely disappeared within 5 days after discontinuation of zonisamide. The exact same episodes relapsed within days after re-administration of zonisamide and disappeared again shortly after discontinuation of zonisamide. Dose adjustments of other anti-seizure medications in case 2 did not result in significant changes in these behavior episodes. Although psychiatric adverse effects including aggressive behavior associated with zonisamide are widely recognized in humans, this is the first report in dogs in the clinical setting. Frontiers Media S.A. 2021-10-29 /pmc/articles/PMC8589241/ /pubmed/34778438 http://dx.doi.org/10.3389/fvets.2021.763822 Text en Copyright © 2021 Kanazono, Ukai and Hiramoto. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Kanazono, Shinichi
Ukai, Masayasu
Hiramoto, Akira
Abnormal Behavior Episodes Associated With Zonisamide in Three Dogs: A Case Report
title Abnormal Behavior Episodes Associated With Zonisamide in Three Dogs: A Case Report
title_full Abnormal Behavior Episodes Associated With Zonisamide in Three Dogs: A Case Report
title_fullStr Abnormal Behavior Episodes Associated With Zonisamide in Three Dogs: A Case Report
title_full_unstemmed Abnormal Behavior Episodes Associated With Zonisamide in Three Dogs: A Case Report
title_short Abnormal Behavior Episodes Associated With Zonisamide in Three Dogs: A Case Report
title_sort abnormal behavior episodes associated with zonisamide in three dogs: a case report
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589241/
https://www.ncbi.nlm.nih.gov/pubmed/34778438
http://dx.doi.org/10.3389/fvets.2021.763822
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