Cell size is a determinant of stem cell potential during aging

Stem cells are remarkably small. Whether small size is important for stem cell function is unknown. We find that hematopoietic stem cells (HSCs) enlarge under conditions known to decrease stem cell function. This decreased fitness of large HSCs is due to reduced proliferation and was accompanied by...

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Autores principales: Lengefeld, Jette, Cheng, Chia-Wei, Maretich, Pema, Blair, Marguerite, Hagen, Hannah, McReynolds, Melanie R., Sullivan, Emily, Majors, Kyra, Roberts, Christina, Kang, Joon Ho, Steiner, Joachim D., Miettinen, Teemu P., Manalis, Scott R., Antebi, Adam, Morrison, Sean J., Lees, Jacqueline A., Boyer, Laurie A., Yilmaz, Ömer H., Amon, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589318/
https://www.ncbi.nlm.nih.gov/pubmed/34767451
http://dx.doi.org/10.1126/sciadv.abk0271
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author Lengefeld, Jette
Cheng, Chia-Wei
Maretich, Pema
Blair, Marguerite
Hagen, Hannah
McReynolds, Melanie R.
Sullivan, Emily
Majors, Kyra
Roberts, Christina
Kang, Joon Ho
Steiner, Joachim D.
Miettinen, Teemu P.
Manalis, Scott R.
Antebi, Adam
Morrison, Sean J.
Lees, Jacqueline A.
Boyer, Laurie A.
Yilmaz, Ömer H.
Amon, Angelika
author_facet Lengefeld, Jette
Cheng, Chia-Wei
Maretich, Pema
Blair, Marguerite
Hagen, Hannah
McReynolds, Melanie R.
Sullivan, Emily
Majors, Kyra
Roberts, Christina
Kang, Joon Ho
Steiner, Joachim D.
Miettinen, Teemu P.
Manalis, Scott R.
Antebi, Adam
Morrison, Sean J.
Lees, Jacqueline A.
Boyer, Laurie A.
Yilmaz, Ömer H.
Amon, Angelika
author_sort Lengefeld, Jette
collection PubMed
description Stem cells are remarkably small. Whether small size is important for stem cell function is unknown. We find that hematopoietic stem cells (HSCs) enlarge under conditions known to decrease stem cell function. This decreased fitness of large HSCs is due to reduced proliferation and was accompanied by altered metabolism. Preventing HSC enlargement or reducing large HSCs in size averts the loss of stem cell potential under conditions causing stem cell exhaustion. Last, we show that murine and human HSCs enlarge during aging. Preventing this age-dependent enlargement improves HSC function. We conclude that small cell size is important for stem cell function in vivo and propose that stem cell enlargement contributes to their functional decline during aging.
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spelling pubmed-85893182021-11-18 Cell size is a determinant of stem cell potential during aging Lengefeld, Jette Cheng, Chia-Wei Maretich, Pema Blair, Marguerite Hagen, Hannah McReynolds, Melanie R. Sullivan, Emily Majors, Kyra Roberts, Christina Kang, Joon Ho Steiner, Joachim D. Miettinen, Teemu P. Manalis, Scott R. Antebi, Adam Morrison, Sean J. Lees, Jacqueline A. Boyer, Laurie A. Yilmaz, Ömer H. Amon, Angelika Sci Adv Biomedicine and Life Sciences Stem cells are remarkably small. Whether small size is important for stem cell function is unknown. We find that hematopoietic stem cells (HSCs) enlarge under conditions known to decrease stem cell function. This decreased fitness of large HSCs is due to reduced proliferation and was accompanied by altered metabolism. Preventing HSC enlargement or reducing large HSCs in size averts the loss of stem cell potential under conditions causing stem cell exhaustion. Last, we show that murine and human HSCs enlarge during aging. Preventing this age-dependent enlargement improves HSC function. We conclude that small cell size is important for stem cell function in vivo and propose that stem cell enlargement contributes to their functional decline during aging. American Association for the Advancement of Science 2021-11-12 /pmc/articles/PMC8589318/ /pubmed/34767451 http://dx.doi.org/10.1126/sciadv.abk0271 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Biomedicine and Life Sciences
Lengefeld, Jette
Cheng, Chia-Wei
Maretich, Pema
Blair, Marguerite
Hagen, Hannah
McReynolds, Melanie R.
Sullivan, Emily
Majors, Kyra
Roberts, Christina
Kang, Joon Ho
Steiner, Joachim D.
Miettinen, Teemu P.
Manalis, Scott R.
Antebi, Adam
Morrison, Sean J.
Lees, Jacqueline A.
Boyer, Laurie A.
Yilmaz, Ömer H.
Amon, Angelika
Cell size is a determinant of stem cell potential during aging
title Cell size is a determinant of stem cell potential during aging
title_full Cell size is a determinant of stem cell potential during aging
title_fullStr Cell size is a determinant of stem cell potential during aging
title_full_unstemmed Cell size is a determinant of stem cell potential during aging
title_short Cell size is a determinant of stem cell potential during aging
title_sort cell size is a determinant of stem cell potential during aging
topic Biomedicine and Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589318/
https://www.ncbi.nlm.nih.gov/pubmed/34767451
http://dx.doi.org/10.1126/sciadv.abk0271
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