Cell size is a determinant of stem cell potential during aging

Stem cells are remarkably small. Whether small size is important for stem cell function is unknown. We find that hematopoietic stem cells (HSCs) enlarge under conditions known to decrease stem cell function. This decreased fitness of large HSCs is due to reduced proliferation and was accompanied by...

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Detalles Bibliográficos
Autores principales: Lengefeld, Jette, Cheng, Chia-Wei, Maretich, Pema, Blair, Marguerite, Hagen, Hannah, McReynolds, Melanie R., Sullivan, Emily, Majors, Kyra, Roberts, Christina, Kang, Joon Ho, Steiner, Joachim D., Miettinen, Teemu P., Manalis, Scott R., Antebi, Adam, Morrison, Sean J., Lees, Jacqueline A., Boyer, Laurie A., Yilmaz, Ömer H., Amon, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589318/
https://www.ncbi.nlm.nih.gov/pubmed/34767451
http://dx.doi.org/10.1126/sciadv.abk0271

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