Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1

How activation of PINK1 and Parkin leads to elimination of damaged mitochondria by mitophagy is largely based on cell lines with few studies in neurons. Here, we have undertaken proteomic analysis of mitochondria from mouse neurons to identify ubiquitylated substrates of endogenous Parkin. Comparati...

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Detalles Bibliográficos
Autores principales: Antico, Odetta, Ordureau, Alban, Stevens, Michael, Singh, Francois, Nirujogi, Raja S., Gierlinski, Marek, Barini, Erica, Rickwood, Mollie L., Prescott, Alan, Toth, Rachel, Ganley, Ian G., Harper, J. Wade, Muqit, Miratul M. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589319/
https://www.ncbi.nlm.nih.gov/pubmed/34767452
http://dx.doi.org/10.1126/sciadv.abj0722

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