Ser9 phosphorylation of GSK-3β promotes aging in the heart through suppression of autophagy

INTRODUCTION: Glycogen synthase kinase-3β (GSK-3β) is a serine/threonine kinase and a negative regulator of cardiac hypertrophy. Phosphorylation of GSK-3β at Ser9 negatively regulates its kinase activity. The role of GSK-3β in cardiac aging remains poorly understood. AIM: The study aimed to elucidat...

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Detalles Bibliográficos
Autores principales: Chen, Yanbin, Maejima, Yasuhiro, Shirakabe, Akihiro, Yamamoto, Takanobu, Ikeda, Yoshiyuki, Sadoshima, Junichi, Zhai, Peiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589323/
https://www.ncbi.nlm.nih.gov/pubmed/34778891
http://dx.doi.org/10.20517/jca.2021.13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589323/
https://www.ncbi.nlm.nih.gov/pubmed/34778891
http://dx.doi.org/10.20517/jca.2021.13

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