Gastric Intestinal Metaplasia and Its Rapid Progression Toward Gastric Adenocarcinoma: A Call for Clear Patient Management and Awareness

Gastric cancer is one of the leading causes of cancer-related death worldwide. Helicobacter pylori (H. pylori) infection is known to cause gastric adenocarcinoma in a stepwise fashion. Gastric intestinal metaplasia is a known premalignant stage. We report a case of a 70-year-old male patient with ac...

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Autores principales: Al Hennawi, Hussam, Khedr, Anwar, Maan, Ramanpreet K, Albarazi, Mohieddin, Atluri, Purna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589342/
https://www.ncbi.nlm.nih.gov/pubmed/34796052
http://dx.doi.org/10.7759/cureus.18751
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author Al Hennawi, Hussam
Khedr, Anwar
Maan, Ramanpreet K
Albarazi, Mohieddin
Atluri, Purna
author_facet Al Hennawi, Hussam
Khedr, Anwar
Maan, Ramanpreet K
Albarazi, Mohieddin
Atluri, Purna
author_sort Al Hennawi, Hussam
collection PubMed
description Gastric cancer is one of the leading causes of cancer-related death worldwide. Helicobacter pylori (H. pylori) infection is known to cause gastric adenocarcinoma in a stepwise fashion. Gastric intestinal metaplasia is a known premalignant stage. We report a case of a 70-year-old male patient with active chronic H. pylori-associated gastritis and focal intestinal metaplasia on the initial presentation, who rapidly developed diffuse, poorly differentiated gastric adenocarcinoma 20 months after the loss to follow-up. Our case highlights the premalignant nature of gastric intestinal metaplasia (GIM) and the extreme importance of early eradication of H. pylori. We also address the lack of definitive GIM surveillance guidelines.
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spelling pubmed-85893422021-11-17 Gastric Intestinal Metaplasia and Its Rapid Progression Toward Gastric Adenocarcinoma: A Call for Clear Patient Management and Awareness Al Hennawi, Hussam Khedr, Anwar Maan, Ramanpreet K Albarazi, Mohieddin Atluri, Purna Cureus Internal Medicine Gastric cancer is one of the leading causes of cancer-related death worldwide. Helicobacter pylori (H. pylori) infection is known to cause gastric adenocarcinoma in a stepwise fashion. Gastric intestinal metaplasia is a known premalignant stage. We report a case of a 70-year-old male patient with active chronic H. pylori-associated gastritis and focal intestinal metaplasia on the initial presentation, who rapidly developed diffuse, poorly differentiated gastric adenocarcinoma 20 months after the loss to follow-up. Our case highlights the premalignant nature of gastric intestinal metaplasia (GIM) and the extreme importance of early eradication of H. pylori. We also address the lack of definitive GIM surveillance guidelines. Cureus 2021-10-13 /pmc/articles/PMC8589342/ /pubmed/34796052 http://dx.doi.org/10.7759/cureus.18751 Text en Copyright © 2021, Al Hennawi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Al Hennawi, Hussam
Khedr, Anwar
Maan, Ramanpreet K
Albarazi, Mohieddin
Atluri, Purna
Gastric Intestinal Metaplasia and Its Rapid Progression Toward Gastric Adenocarcinoma: A Call for Clear Patient Management and Awareness
title Gastric Intestinal Metaplasia and Its Rapid Progression Toward Gastric Adenocarcinoma: A Call for Clear Patient Management and Awareness
title_full Gastric Intestinal Metaplasia and Its Rapid Progression Toward Gastric Adenocarcinoma: A Call for Clear Patient Management and Awareness
title_fullStr Gastric Intestinal Metaplasia and Its Rapid Progression Toward Gastric Adenocarcinoma: A Call for Clear Patient Management and Awareness
title_full_unstemmed Gastric Intestinal Metaplasia and Its Rapid Progression Toward Gastric Adenocarcinoma: A Call for Clear Patient Management and Awareness
title_short Gastric Intestinal Metaplasia and Its Rapid Progression Toward Gastric Adenocarcinoma: A Call for Clear Patient Management and Awareness
title_sort gastric intestinal metaplasia and its rapid progression toward gastric adenocarcinoma: a call for clear patient management and awareness
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589342/
https://www.ncbi.nlm.nih.gov/pubmed/34796052
http://dx.doi.org/10.7759/cureus.18751
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