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Vitamin D receptor gene polymorphisms in atopy

BACKGROUND: The occurrence of allergic conditions, for example allergic asthma, rhinitis, and atopic dermatitis, is rising worldwide. These allergic conditions are associated with poor life quality. Vitamin D is proposed to be linked with increased risk and severe forms of allergic diseases. AIMS: T...

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Autores principales: Tamasauskiene, Laura, Golubickaite, Ieva, Ugenskiene, Rasa, Sjakste, Nikolajs, Paramonova, Natalia, Wu, Lawrence Shih‐Hsin, Wang, Lawrence Shih‐Jiu‐Yao, Sitkauskiene, Brigita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589349/
https://www.ncbi.nlm.nih.gov/pubmed/34343413
http://dx.doi.org/10.1002/iid3.487
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author Tamasauskiene, Laura
Golubickaite, Ieva
Ugenskiene, Rasa
Sjakste, Nikolajs
Paramonova, Natalia
Wu, Lawrence Shih‐Hsin
Wang, Lawrence Shih‐Jiu‐Yao
Sitkauskiene, Brigita
author_facet Tamasauskiene, Laura
Golubickaite, Ieva
Ugenskiene, Rasa
Sjakste, Nikolajs
Paramonova, Natalia
Wu, Lawrence Shih‐Hsin
Wang, Lawrence Shih‐Jiu‐Yao
Sitkauskiene, Brigita
author_sort Tamasauskiene, Laura
collection PubMed
description BACKGROUND: The occurrence of allergic conditions, for example allergic asthma, rhinitis, and atopic dermatitis, is rising worldwide. These allergic conditions are associated with poor life quality. Vitamin D is proposed to be linked with increased risk and severe forms of allergic diseases. AIMS: This review article aimed to evaluate the vitamin D level role and polymorphisms of vitamin D receptor gene (VDR) in atopy. METHODS & MATERIALS: We analyzed publications that were focusing on levels of vitamin D and/or polymorphism analysis of vitamin D receptor gene in allergic asthma, rhinitis, and atopic dermatitis patients. RESULTS: We noticed that levels of vitamin D are extensively studied in atopy by many research groups, however, polymorphisms of vitamin D receptor gene and their link with levels of vitamin D lack comprehensive data. There is evidence that vitamin D may be associated with anti‐inflammatory effects in allergic diseases. Some of VDR polymorphisms also may play a role in pathogenesis of these diseases. However, the data from different studies are controversial. DISCUSSION: The results of different studies are usually inconsistent, most probably due to populational bias or differences in methodology. Even though, more evidence shows a positive impact of vitamin D on the risk and outcomes of allergic diseases, especially atopic dermatitis, and asthma. CONCLUSIONS: There is controversial data about the level of vitamin D and its role in atopy; however, more evidence shows a positive impact on the risk and outcomes of allergic diseases.
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spelling pubmed-85893492021-11-19 Vitamin D receptor gene polymorphisms in atopy Tamasauskiene, Laura Golubickaite, Ieva Ugenskiene, Rasa Sjakste, Nikolajs Paramonova, Natalia Wu, Lawrence Shih‐Hsin Wang, Lawrence Shih‐Jiu‐Yao Sitkauskiene, Brigita Immun Inflamm Dis Review Articles BACKGROUND: The occurrence of allergic conditions, for example allergic asthma, rhinitis, and atopic dermatitis, is rising worldwide. These allergic conditions are associated with poor life quality. Vitamin D is proposed to be linked with increased risk and severe forms of allergic diseases. AIMS: This review article aimed to evaluate the vitamin D level role and polymorphisms of vitamin D receptor gene (VDR) in atopy. METHODS & MATERIALS: We analyzed publications that were focusing on levels of vitamin D and/or polymorphism analysis of vitamin D receptor gene in allergic asthma, rhinitis, and atopic dermatitis patients. RESULTS: We noticed that levels of vitamin D are extensively studied in atopy by many research groups, however, polymorphisms of vitamin D receptor gene and their link with levels of vitamin D lack comprehensive data. There is evidence that vitamin D may be associated with anti‐inflammatory effects in allergic diseases. Some of VDR polymorphisms also may play a role in pathogenesis of these diseases. However, the data from different studies are controversial. DISCUSSION: The results of different studies are usually inconsistent, most probably due to populational bias or differences in methodology. Even though, more evidence shows a positive impact of vitamin D on the risk and outcomes of allergic diseases, especially atopic dermatitis, and asthma. CONCLUSIONS: There is controversial data about the level of vitamin D and its role in atopy; however, more evidence shows a positive impact on the risk and outcomes of allergic diseases. John Wiley and Sons Inc. 2021-08-03 /pmc/articles/PMC8589349/ /pubmed/34343413 http://dx.doi.org/10.1002/iid3.487 Text en © 2021 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Tamasauskiene, Laura
Golubickaite, Ieva
Ugenskiene, Rasa
Sjakste, Nikolajs
Paramonova, Natalia
Wu, Lawrence Shih‐Hsin
Wang, Lawrence Shih‐Jiu‐Yao
Sitkauskiene, Brigita
Vitamin D receptor gene polymorphisms in atopy
title Vitamin D receptor gene polymorphisms in atopy
title_full Vitamin D receptor gene polymorphisms in atopy
title_fullStr Vitamin D receptor gene polymorphisms in atopy
title_full_unstemmed Vitamin D receptor gene polymorphisms in atopy
title_short Vitamin D receptor gene polymorphisms in atopy
title_sort vitamin d receptor gene polymorphisms in atopy
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589349/
https://www.ncbi.nlm.nih.gov/pubmed/34343413
http://dx.doi.org/10.1002/iid3.487
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