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Cell therapy for cartilage repair

Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of tissues and organs, offers great hope for the future of medicine. Cell therapy for treating defects in articular cartilage has been an exemplar of translating this technology to the clinic, but it is not witho...

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Detalles Bibliográficos
Autores principales: Hulme, Charlotte H., Perry, Jade, McCarthy, Helen S., Wright, Karina T., Snow, Martyn, Mennan, Claire, Roberts, Sally
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589441/
https://www.ncbi.nlm.nih.gov/pubmed/34423830
http://dx.doi.org/10.1042/ETLS20210015
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author Hulme, Charlotte H.
Perry, Jade
McCarthy, Helen S.
Wright, Karina T.
Snow, Martyn
Mennan, Claire
Roberts, Sally
author_facet Hulme, Charlotte H.
Perry, Jade
McCarthy, Helen S.
Wright, Karina T.
Snow, Martyn
Mennan, Claire
Roberts, Sally
author_sort Hulme, Charlotte H.
collection PubMed
description Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of tissues and organs, offers great hope for the future of medicine. Cell therapy for treating defects in articular cartilage has been an exemplar of translating this technology to the clinic, but it is not without its challenges. These include applying regulations, which were designed for pharmaceutical agents, to living cells. In addition, using autologous cells as the therapeutic agent brings additional costs and logistical challenges compared with using allogeneic cells. The main cell types used in treating chondral or osteochondral defects in joints to date are chondrocytes and mesenchymal stromal cells derived from various sources such as bone marrow, adipose tissue or umbilical cord. This review discusses some of their biology and pre-clinical studies before describing the most pertinent clinical trials in this area.
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spelling pubmed-85894412021-11-18 Cell therapy for cartilage repair Hulme, Charlotte H. Perry, Jade McCarthy, Helen S. Wright, Karina T. Snow, Martyn Mennan, Claire Roberts, Sally Emerg Top Life Sci Review Articles Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of tissues and organs, offers great hope for the future of medicine. Cell therapy for treating defects in articular cartilage has been an exemplar of translating this technology to the clinic, but it is not without its challenges. These include applying regulations, which were designed for pharmaceutical agents, to living cells. In addition, using autologous cells as the therapeutic agent brings additional costs and logistical challenges compared with using allogeneic cells. The main cell types used in treating chondral or osteochondral defects in joints to date are chondrocytes and mesenchymal stromal cells derived from various sources such as bone marrow, adipose tissue or umbilical cord. This review discusses some of their biology and pre-clinical studies before describing the most pertinent clinical trials in this area. Portland Press Ltd. 2021-10-29 2021-08-23 /pmc/articles/PMC8589441/ /pubmed/34423830 http://dx.doi.org/10.1042/ETLS20210015 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Articles
Hulme, Charlotte H.
Perry, Jade
McCarthy, Helen S.
Wright, Karina T.
Snow, Martyn
Mennan, Claire
Roberts, Sally
Cell therapy for cartilage repair
title Cell therapy for cartilage repair
title_full Cell therapy for cartilage repair
title_fullStr Cell therapy for cartilage repair
title_full_unstemmed Cell therapy for cartilage repair
title_short Cell therapy for cartilage repair
title_sort cell therapy for cartilage repair
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589441/
https://www.ncbi.nlm.nih.gov/pubmed/34423830
http://dx.doi.org/10.1042/ETLS20210015
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