High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer

This study is aimed at exploring the potential role of GSDMC in kidney renal clear cell carcinoma (KIRC). We analyzed the expression of GSDMC in 33 types of cancers in TCGA database. The results showed that the expression of GSDMC was upregulated in most cancers. We found a significant association b...

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Autores principales: Cui, Yun-Qian, Meng, Fei, Zhan, Wen-Li, Dai, Zhou-Tong, Liao, Xinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589493/
https://www.ncbi.nlm.nih.gov/pubmed/34778452
http://dx.doi.org/10.1155/2021/5282894
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author Cui, Yun-Qian
Meng, Fei
Zhan, Wen-Li
Dai, Zhou-Tong
Liao, Xinghua
author_facet Cui, Yun-Qian
Meng, Fei
Zhan, Wen-Li
Dai, Zhou-Tong
Liao, Xinghua
author_sort Cui, Yun-Qian
collection PubMed
description This study is aimed at exploring the potential role of GSDMC in kidney renal clear cell carcinoma (KIRC). We analyzed the expression of GSDMC in 33 types of cancers in TCGA database. The results showed that the expression of GSDMC was upregulated in most cancers. We found a significant association between high expression of GSDMC and shortened patient overall survival, progression-free survival, and disease-specific survival. In vitro experiments have shown that the expression of GSDMC was significantly elevated in KIRC cell lines. Moreover, decreased expression of GSDMC was significantly associated with decreased cell proliferation. In summary, we believe that this study provides valuable data supporting future clinical treatment.
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spelling pubmed-85894932021-11-13 High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer Cui, Yun-Qian Meng, Fei Zhan, Wen-Li Dai, Zhou-Tong Liao, Xinghua Biomed Res Int Research Article This study is aimed at exploring the potential role of GSDMC in kidney renal clear cell carcinoma (KIRC). We analyzed the expression of GSDMC in 33 types of cancers in TCGA database. The results showed that the expression of GSDMC was upregulated in most cancers. We found a significant association between high expression of GSDMC and shortened patient overall survival, progression-free survival, and disease-specific survival. In vitro experiments have shown that the expression of GSDMC was significantly elevated in KIRC cell lines. Moreover, decreased expression of GSDMC was significantly associated with decreased cell proliferation. In summary, we believe that this study provides valuable data supporting future clinical treatment. Hindawi 2021-11-05 /pmc/articles/PMC8589493/ /pubmed/34778452 http://dx.doi.org/10.1155/2021/5282894 Text en Copyright © 2021 Yun-Qian Cui et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cui, Yun-Qian
Meng, Fei
Zhan, Wen-Li
Dai, Zhou-Tong
Liao, Xinghua
High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer
title High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer
title_full High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer
title_fullStr High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer
title_full_unstemmed High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer
title_short High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer
title_sort high expression of gsdmc is associated with poor survival in kidney clear cell cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589493/
https://www.ncbi.nlm.nih.gov/pubmed/34778452
http://dx.doi.org/10.1155/2021/5282894
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AT zhanwenli highexpressionofgsdmcisassociatedwithpoorsurvivalinkidneyclearcellcancer
AT daizhoutong highexpressionofgsdmcisassociatedwithpoorsurvivalinkidneyclearcellcancer
AT liaoxinghua highexpressionofgsdmcisassociatedwithpoorsurvivalinkidneyclearcellcancer

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