Cargando…

Peripheral Immune Cells Exhaustion and Functional Impairment in Patients With Chronic Hepatitis B

After infection of hepatitis B virus (HBV), the virus induces a variety of immune disorders in the host, leading to immune escape and, finally, the chronicity of the disease. This study investigated immune cell defects and functional impairment in patients with chronic hepatitis B (CHB). We analyzed...

Descripción completa

Detalles Bibliográficos
Autores principales: Jin, Xin, Yan, Zhi-han, Lu, Lingna, Lu, Shengjia, Zhang, Guoping, Lin, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589627/
https://www.ncbi.nlm.nih.gov/pubmed/34782855
http://dx.doi.org/10.3389/fmed.2021.759292
_version_ 1784598770372050944
author Jin, Xin
Yan, Zhi-han
Lu, Lingna
Lu, Shengjia
Zhang, Guoping
Lin, Wei
author_facet Jin, Xin
Yan, Zhi-han
Lu, Lingna
Lu, Shengjia
Zhang, Guoping
Lin, Wei
author_sort Jin, Xin
collection PubMed
description After infection of hepatitis B virus (HBV), the virus induces a variety of immune disorders in the host, leading to immune escape and, finally, the chronicity of the disease. This study investigated immune cell defects and functional impairment in patients with chronic hepatitis B (CHB). We analyzed the percentage, function, and phenotypes of various immune cell subpopulations in the peripheral blood along with the concentrations of cytokines in the plasma. We compared the results between patients with CHB and healthy individuals. It was found that in patients with CHB, the cell function was impaired and, there was increased expression of inhibitory receptors, such as NKG2A and PD-1 in both NK and T cells. The impairment of function was mainly in cytokine secretion, and the cytotoxicity was not significantly diminished. We also found that the proportion of dendritic cells (DC) decreased and regulatory B cells (Breg) increased in CHB. In addition, the Breg cells were negatively correlated with T cell cytokine and positively correlated with ALT and HBV viral load. Taken together, various disorders and functional impairments were found in the immune cells of peripheral blood in CHB patients, especially NK and T cells. These cells showed exhaustion and the increase of regulatory B cells may be one of the reasons for this phenomenon.
format Online
Article
Text
id pubmed-8589627
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-85896272021-11-14 Peripheral Immune Cells Exhaustion and Functional Impairment in Patients With Chronic Hepatitis B Jin, Xin Yan, Zhi-han Lu, Lingna Lu, Shengjia Zhang, Guoping Lin, Wei Front Med (Lausanne) Medicine After infection of hepatitis B virus (HBV), the virus induces a variety of immune disorders in the host, leading to immune escape and, finally, the chronicity of the disease. This study investigated immune cell defects and functional impairment in patients with chronic hepatitis B (CHB). We analyzed the percentage, function, and phenotypes of various immune cell subpopulations in the peripheral blood along with the concentrations of cytokines in the plasma. We compared the results between patients with CHB and healthy individuals. It was found that in patients with CHB, the cell function was impaired and, there was increased expression of inhibitory receptors, such as NKG2A and PD-1 in both NK and T cells. The impairment of function was mainly in cytokine secretion, and the cytotoxicity was not significantly diminished. We also found that the proportion of dendritic cells (DC) decreased and regulatory B cells (Breg) increased in CHB. In addition, the Breg cells were negatively correlated with T cell cytokine and positively correlated with ALT and HBV viral load. Taken together, various disorders and functional impairments were found in the immune cells of peripheral blood in CHB patients, especially NK and T cells. These cells showed exhaustion and the increase of regulatory B cells may be one of the reasons for this phenomenon. Frontiers Media S.A. 2021-10-26 /pmc/articles/PMC8589627/ /pubmed/34782855 http://dx.doi.org/10.3389/fmed.2021.759292 Text en Copyright © 2021 Jin, Yan, Lu, Lu, Zhang and Lin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Jin, Xin
Yan, Zhi-han
Lu, Lingna
Lu, Shengjia
Zhang, Guoping
Lin, Wei
Peripheral Immune Cells Exhaustion and Functional Impairment in Patients With Chronic Hepatitis B
title Peripheral Immune Cells Exhaustion and Functional Impairment in Patients With Chronic Hepatitis B
title_full Peripheral Immune Cells Exhaustion and Functional Impairment in Patients With Chronic Hepatitis B
title_fullStr Peripheral Immune Cells Exhaustion and Functional Impairment in Patients With Chronic Hepatitis B
title_full_unstemmed Peripheral Immune Cells Exhaustion and Functional Impairment in Patients With Chronic Hepatitis B
title_short Peripheral Immune Cells Exhaustion and Functional Impairment in Patients With Chronic Hepatitis B
title_sort peripheral immune cells exhaustion and functional impairment in patients with chronic hepatitis b
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589627/
https://www.ncbi.nlm.nih.gov/pubmed/34782855
http://dx.doi.org/10.3389/fmed.2021.759292
work_keys_str_mv AT jinxin peripheralimmunecellsexhaustionandfunctionalimpairmentinpatientswithchronichepatitisb
AT yanzhihan peripheralimmunecellsexhaustionandfunctionalimpairmentinpatientswithchronichepatitisb
AT lulingna peripheralimmunecellsexhaustionandfunctionalimpairmentinpatientswithchronichepatitisb
AT lushengjia peripheralimmunecellsexhaustionandfunctionalimpairmentinpatientswithchronichepatitisb
AT zhangguoping peripheralimmunecellsexhaustionandfunctionalimpairmentinpatientswithchronichepatitisb
AT linwei peripheralimmunecellsexhaustionandfunctionalimpairmentinpatientswithchronichepatitisb