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A specific neural substrate predicting current and future impulsivity in young adults
Impulsivity (rash action with deleterious outcomes) is common to many psychiatric disorders. While some studies indicate altered amygdala and prefrontal cortical (PFC) activity associated with impulsivity, it remains unclear whether these patterns of neural activity are specific to impulsivity or co...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589683/ https://www.ncbi.nlm.nih.gov/pubmed/33495543 http://dx.doi.org/10.1038/s41380-021-01017-0 |
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author | Steele, J. Scott Bertocci, Michele Eckstrand, Kristen Chase, Henry W. Stiffler, Richelle Aslam, Haris Lockovich, Jeanette Bebko, Genna Phillips, Mary L. |
author_facet | Steele, J. Scott Bertocci, Michele Eckstrand, Kristen Chase, Henry W. Stiffler, Richelle Aslam, Haris Lockovich, Jeanette Bebko, Genna Phillips, Mary L. |
author_sort | Steele, J. Scott |
collection | PubMed |
description | Impulsivity (rash action with deleterious outcomes) is common to many psychiatric disorders. While some studies indicate altered amygdala and prefrontal cortical (PFC) activity associated with impulsivity, it remains unclear whether these patterns of neural activity are specific to impulsivity or common to a range of affective and anxiety symptoms. To elucidate neural markers specific to impulsivity, we aimed to differentiate patterns of amygdala–PFC activity and functional connectivity associated with impulsivity from those associated with affective and anxiety symptoms, and identify measures of this circuitry predicting future worsening of impulsivity. Using a face emotion processing task that reliably activates amygdala–PFC circuitry, neural activity and connectivity were assessed in a transdiagnostically-recruited sample of young adults, including healthy (N = 47) and treatment-seeking individuals (N = 67). Relationships were examined between neural measures and impulsivity, anhedonia, and affective and anxiety symptoms at baseline (N = 114), and at 6 months post scan (N = 30). Impulsivity, particularly negative urgency and lack of perseverance, was related to greater amygdala activity (beta = 0.82, p = 0.003; beta = 0.68, p = 0.004; respectively) and lower amygdala–medial PFC functional connectivity (voxels = 60, t(peak) = 4.45, p(FWE) = 0.017; voxels = 335, t(peak) = 5.26, p(FWE) = 0.001; respectively) to facial fear. Left vlPFC, but not amygdala, activity to facial anger was inversely associated with mania/hypomania (beta = −2.08, p = 0.018). Impulsivity 6 months later was predicted by amygdala activity to facial sadness (beta = 0.50, p = 0.017). There were no other significant relationships between neural activity and 6-month anhedonia, affective, and anxiety symptoms. Our findings are the first to associate amygdala–PFC activity and functional connectivity with impulsivity in a large, transdiagnostic sample, providing neural targets for future interventions to reduce predisposition to impulsivity and related future mental health problems in young adults. |
format | Online Article Text |
id | pubmed-8589683 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-85896832021-11-23 A specific neural substrate predicting current and future impulsivity in young adults Steele, J. Scott Bertocci, Michele Eckstrand, Kristen Chase, Henry W. Stiffler, Richelle Aslam, Haris Lockovich, Jeanette Bebko, Genna Phillips, Mary L. Mol Psychiatry Article Impulsivity (rash action with deleterious outcomes) is common to many psychiatric disorders. While some studies indicate altered amygdala and prefrontal cortical (PFC) activity associated with impulsivity, it remains unclear whether these patterns of neural activity are specific to impulsivity or common to a range of affective and anxiety symptoms. To elucidate neural markers specific to impulsivity, we aimed to differentiate patterns of amygdala–PFC activity and functional connectivity associated with impulsivity from those associated with affective and anxiety symptoms, and identify measures of this circuitry predicting future worsening of impulsivity. Using a face emotion processing task that reliably activates amygdala–PFC circuitry, neural activity and connectivity were assessed in a transdiagnostically-recruited sample of young adults, including healthy (N = 47) and treatment-seeking individuals (N = 67). Relationships were examined between neural measures and impulsivity, anhedonia, and affective and anxiety symptoms at baseline (N = 114), and at 6 months post scan (N = 30). Impulsivity, particularly negative urgency and lack of perseverance, was related to greater amygdala activity (beta = 0.82, p = 0.003; beta = 0.68, p = 0.004; respectively) and lower amygdala–medial PFC functional connectivity (voxels = 60, t(peak) = 4.45, p(FWE) = 0.017; voxels = 335, t(peak) = 5.26, p(FWE) = 0.001; respectively) to facial fear. Left vlPFC, but not amygdala, activity to facial anger was inversely associated with mania/hypomania (beta = −2.08, p = 0.018). Impulsivity 6 months later was predicted by amygdala activity to facial sadness (beta = 0.50, p = 0.017). There were no other significant relationships between neural activity and 6-month anhedonia, affective, and anxiety symptoms. Our findings are the first to associate amygdala–PFC activity and functional connectivity with impulsivity in a large, transdiagnostic sample, providing neural targets for future interventions to reduce predisposition to impulsivity and related future mental health problems in young adults. Nature Publishing Group UK 2021-01-25 2021 /pmc/articles/PMC8589683/ /pubmed/33495543 http://dx.doi.org/10.1038/s41380-021-01017-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Steele, J. Scott Bertocci, Michele Eckstrand, Kristen Chase, Henry W. Stiffler, Richelle Aslam, Haris Lockovich, Jeanette Bebko, Genna Phillips, Mary L. A specific neural substrate predicting current and future impulsivity in young adults |
title | A specific neural substrate predicting current and future impulsivity in young adults |
title_full | A specific neural substrate predicting current and future impulsivity in young adults |
title_fullStr | A specific neural substrate predicting current and future impulsivity in young adults |
title_full_unstemmed | A specific neural substrate predicting current and future impulsivity in young adults |
title_short | A specific neural substrate predicting current and future impulsivity in young adults |
title_sort | specific neural substrate predicting current and future impulsivity in young adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589683/ https://www.ncbi.nlm.nih.gov/pubmed/33495543 http://dx.doi.org/10.1038/s41380-021-01017-0 |
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