SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains

SARS-CoV-2 variants of concern (VOC) B.1.1.7 (alpha) and B.1.351 (beta) show increased transmissibility and enhanced antibody neutralization resistance. Here we demonstrate in K18-hACE2 transgenic mice that B.1.1.7 and B.1.351 are 100-fold more lethal than the original SARS-CoV-2 bearing 614D. B.1.1...

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Detalles Bibliográficos
Autores principales: Radvak, Peter, Kwon, Hyung-Joon, Kosikova, Martina, Ortega-Rodriguez, Uriel, Xiang, Ruoxuan, Phue, Je-Nie, Shen, Rong-Fong, Rozzelle, James, Kapoor, Neeraj, Rabara, Taylor, Fairman, Jeff, Xie, Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589842/
https://www.ncbi.nlm.nih.gov/pubmed/34772941
http://dx.doi.org/10.1038/s41467-021-26803-w

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