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In vitro and in silico characterization of adiponectin-receptor agonist dipeptides

The aim of this study is to develop a dipeptide showing an adiponectin receptor 1 (AdipoR1) agonistic effect in skeletal muscle L6 myotubes. Based on the structure of the AdipoR1 agonist, AdipoRon, 15 synthetic dipeptides were targeted to promote glucose uptake in L6 myotubes. Tyr-Pro showed a signi...

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Detalles Bibliográficos
Autores principales:	Lee, Yuna, Nakano, Akihiro, Nakamura, Saya, Sakai, Kenta, Tanaka, Mitsuru, Sanematsu, Keisuke, Shigemura, Noriatsu, Matsui, Toshiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589863/ https://www.ncbi.nlm.nih.gov/pubmed/34772952 http://dx.doi.org/10.1038/s41538-021-00114-2

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