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The development of microfabricated solenoids with magnetic cores for micromagnetic neural stimulation

Electrical stimulation via invasive microelectrodes is commonly used to treat a wide range of neurological and psychiatric conditions. Despite its remarkable success, the stimulation performance is not sustainable since the electrodes become encapsulated by gliosis due to foreign body reactions. Mag...

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Autores principales: Khalifa, Adam, Zaeimbashi, Mohsen, Zhou, Tony X., Abrishami, Seyed Mahdi, Sun, Neville, Park, Seunghyun, Šumarac, Tamara, Qu, Jason, Zohar, Inbar, Yacoby, Amir, Cash, Sydney, Sun, Nian X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589949/
https://www.ncbi.nlm.nih.gov/pubmed/34786205
http://dx.doi.org/10.1038/s41378-021-00320-8
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author Khalifa, Adam
Zaeimbashi, Mohsen
Zhou, Tony X.
Abrishami, Seyed Mahdi
Sun, Neville
Park, Seunghyun
Šumarac, Tamara
Qu, Jason
Zohar, Inbar
Yacoby, Amir
Cash, Sydney
Sun, Nian X.
author_facet Khalifa, Adam
Zaeimbashi, Mohsen
Zhou, Tony X.
Abrishami, Seyed Mahdi
Sun, Neville
Park, Seunghyun
Šumarac, Tamara
Qu, Jason
Zohar, Inbar
Yacoby, Amir
Cash, Sydney
Sun, Nian X.
author_sort Khalifa, Adam
collection PubMed
description Electrical stimulation via invasive microelectrodes is commonly used to treat a wide range of neurological and psychiatric conditions. Despite its remarkable success, the stimulation performance is not sustainable since the electrodes become encapsulated by gliosis due to foreign body reactions. Magnetic stimulation overcomes these limitations by eliminating the need for a metal-electrode contact. Here, we demonstrate a novel microfabricated solenoid inductor (80 µm × 40 µm) with a magnetic core that can activate neuronal tissue. The characterization and proof-of-concept of the device raise the possibility that micromagnetic stimulation solenoids that are small enough to be implanted within the brain may prove to be an effective alternative to existing electrode-based stimulation devices for chronic neural interfacing applications.
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spelling pubmed-85899492021-11-15 The development of microfabricated solenoids with magnetic cores for micromagnetic neural stimulation Khalifa, Adam Zaeimbashi, Mohsen Zhou, Tony X. Abrishami, Seyed Mahdi Sun, Neville Park, Seunghyun Šumarac, Tamara Qu, Jason Zohar, Inbar Yacoby, Amir Cash, Sydney Sun, Nian X. Microsyst Nanoeng Article Electrical stimulation via invasive microelectrodes is commonly used to treat a wide range of neurological and psychiatric conditions. Despite its remarkable success, the stimulation performance is not sustainable since the electrodes become encapsulated by gliosis due to foreign body reactions. Magnetic stimulation overcomes these limitations by eliminating the need for a metal-electrode contact. Here, we demonstrate a novel microfabricated solenoid inductor (80 µm × 40 µm) with a magnetic core that can activate neuronal tissue. The characterization and proof-of-concept of the device raise the possibility that micromagnetic stimulation solenoids that are small enough to be implanted within the brain may prove to be an effective alternative to existing electrode-based stimulation devices for chronic neural interfacing applications. Nature Publishing Group UK 2021-11-12 /pmc/articles/PMC8589949/ /pubmed/34786205 http://dx.doi.org/10.1038/s41378-021-00320-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Khalifa, Adam
Zaeimbashi, Mohsen
Zhou, Tony X.
Abrishami, Seyed Mahdi
Sun, Neville
Park, Seunghyun
Šumarac, Tamara
Qu, Jason
Zohar, Inbar
Yacoby, Amir
Cash, Sydney
Sun, Nian X.
The development of microfabricated solenoids with magnetic cores for micromagnetic neural stimulation
title The development of microfabricated solenoids with magnetic cores for micromagnetic neural stimulation
title_full The development of microfabricated solenoids with magnetic cores for micromagnetic neural stimulation
title_fullStr The development of microfabricated solenoids with magnetic cores for micromagnetic neural stimulation
title_full_unstemmed The development of microfabricated solenoids with magnetic cores for micromagnetic neural stimulation
title_short The development of microfabricated solenoids with magnetic cores for micromagnetic neural stimulation
title_sort development of microfabricated solenoids with magnetic cores for micromagnetic neural stimulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589949/
https://www.ncbi.nlm.nih.gov/pubmed/34786205
http://dx.doi.org/10.1038/s41378-021-00320-8
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