Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo

OBJECTIVE: Long-acting glucagon-like peptide-1 receptor agonists (GLP-1RAs), like liraglutide and semaglutide, are viable treatments for diabetes and obesity. Liraglutide directly activates hypothalamic proopiomelanocortin (POMC) neurons while indirectly inhibiting Neuropeptide Y/Agouti-related pept...

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Detalles Bibliográficos
Autores principales: Dong, Yanbin, Carty, Jamie, Goldstein, Nitsan, He, Zhenyan, Hwang, Eunsang, Chau, Dominic, Wallace, Briana, Kabahizi, Anita, Lieu, Linh, Peng, Yunqian, Gao, Yong, Hu, Ling, Betley, J. Nicholas, Williams, Kevin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590079/
https://www.ncbi.nlm.nih.gov/pubmed/34626854
http://dx.doi.org/10.1016/j.molmet.2021.101352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590079/
https://www.ncbi.nlm.nih.gov/pubmed/34626854
http://dx.doi.org/10.1016/j.molmet.2021.101352

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