Cargando…

Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo

OBJECTIVE: Long-acting glucagon-like peptide-1 receptor agonists (GLP-1RAs), like liraglutide and semaglutide, are viable treatments for diabetes and obesity. Liraglutide directly activates hypothalamic proopiomelanocortin (POMC) neurons while indirectly inhibiting Neuropeptide Y/Agouti-related pept...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dong, Yanbin, Carty, Jamie, Goldstein, Nitsan, He, Zhenyan, Hwang, Eunsang, Chau, Dominic, Wallace, Briana, Kabahizi, Anita, Lieu, Linh, Peng, Yunqian, Gao, Yong, Hu, Ling, Betley, J. Nicholas, Williams, Kevin W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590079/ https://www.ncbi.nlm.nih.gov/pubmed/34626854 http://dx.doi.org/10.1016/j.molmet.2021.101352

Ejemplares similares

Cellular and synaptic reorganization of arcuate NPY/AgRP and POMC neurons after exercise
por: He, Zhenyan, et al.
Publicado: (2018)

Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons – Implications for energy balance and glucose control
por: He, Zhenyan, et al.
Publicado: (2019)

Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin
por: Paeger, Lars, et al.
Publicado: (2017)

Sustained inhibition of NPY/AgRP neuronal activity by FGF1
por: Hwang, Eunsang, et al.
Publicado: (2022)

Phosphoinositide 3-Kinase Is Integral for the Acute Activity of Leptin and Insulin in Male Arcuate NPY/AgRP Neurons
por: Huang, Yiru, et al.
Publicado: (2018)

Role of POMC and AgRP neuronal activities on glycaemia in mice
por: Üner, Aykut Göktürk, et al.
Publicado: (2019)

Sustained NPY signaling enables AgRP neurons to drive feeding
por: Chen, Yiming, et al.
Publicado: (2019)

Somato-Dendritic Localization and Signaling by Leptin Receptors in Hypothalamic POMC and AgRP Neurons
por: Ha, Sangdeuk, et al.
Publicado: (2013)

Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons
por: Wang, Daqing, et al.
Publicado: (2015)

NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons
por: Engström Ruud, Linda, et al.
Publicado: (2020)

Local Drd1-neurons input to subgroups of arcuate AgRP/NPY-neurons
por: Chadwick, Sean R., et al.
Publicado: (2022)

Correction: Somato-Dendritic Localization and Signaling by Leptin Receptors in Hypothalamic POMC and AgRP Neurons
por: Ha, Sangdeuk, et al.
Publicado: (2013)

Differential contribution of POMC and AgRP neurons to the regulation of regional autonomic nerve activity by leptin
por: Bell, Balyssa B., et al.
Publicado: (2017)

Insulin Receptor Signaling in POMC, but Not AgRP, Neurons Controls Adipose Tissue Insulin Action
por: Shin, Andrew C., et al.
Publicado: (2017)

Arcuate AgRP, but not POMC neurons, modulate paraventricular CRF synthesis and release in response to fasting
por: Fernandes, Alan Carlos Alves, et al.
Publicado: (2022)

PERK in POMC neurons connects celastrol with metabolism
por: He, Zhenyan, et al.
Publicado: (2021)

AgRP/NPY Neuron Excitability Is Modulated by Metabotropic Glutamate Receptor 1 During Fasting
por: Laing, Brenton T., et al.
Publicado: (2018)

Central α-Klotho Suppresses NPY/AgRP Neuron Activity and Regulates Metabolism in Mice
por: Landry, Taylor, et al.
Publicado: (2020)

Correction to: Arcuate AgRP, but not POMC neurons, modulate paraventricular CRF synthesis and release in response to fasting
por: Fernandes, Alan Carlos Alves, et al.
Publicado: (2022)

A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism
por: He, Yanlin, et al.
Publicado: (2016)

Altered features of neurotransmitters: NPY, α-MSH, and AgRP in type 2 diabetic patients with hypertension
por: Li, Baoxin, et al.
Publicado: (2020)

Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice
por: Smith, Mark A., et al.
Publicado: (2015)

Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales
por: Mandelblat-Cerf, Yael, et al.
Publicado: (2015)

Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP/NPY neurons in mice
por: Wei, Wei, et al.
Publicado: (2015)

Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleus
por: Morozov, Yury M., et al.
Publicado: (2017)

Investigating the NPY/AgRP/GABA to GnRH Neuron Circuit in Prenatally Androgenized PCOS-Like Mice
por: Marshall, Christopher J, et al.
Publicado: (2020)

Glucagon‐like peptide‐1 (GLP‐1) signalling in the brain: From neural circuits and metabolism to therapeutics
por: Kabahizi, Anita, et al.
Publicado: (2021)

Ghrelin signalling in AgRP neurons links metabolic state to the sensory regulation of AgRP neural activity
por: So, Wang Lok, et al.
Publicado: (2023)

Proliferative Hypothalamic Neurospheres Express NPY, AGRP, POMC, CART and Orexin-A and Differentiate to Functional Neurons
por: Sousa-Ferreira, Lígia, et al.
Publicado: (2011)

ARC(AgRP/NPY) Neuron Activity Is Required for Acute Exercise-Induced Food Intake in Un-Trained Mice
por: Bunner, Wyatt, et al.
Publicado: (2020)

Modified Peptide YY Molecule Attenuates the Activity of NPY/AgRP Neurons and Reduces Food Intake in Male Mice
por: Jones, Edward S, et al.
Publicado: (2019)

Enhanced Ghrelin Levels and Hypothalamic Orexigenic AgRP and NPY Neuropeptide Expression in Models of Jejuno-Colonic Short Bowel Syndrome
por: Gillard, Laura, et al.
Publicado: (2016)

CRISPR knockdown of Kcnq3 attenuates the M-current and increases excitability of NPY/AgRP neurons to alter energy balance
por: Stincic, Todd L., et al.
Publicado: (2021)

SUN-LB083 Functional Role of Arcuate Nucleus NPY/AgRP Neurons in the GnRH Circuit Regulating LH Secretion
por: Coutinho, Eulalia, et al.
Publicado: (2019)

Arcuate AgRP neurons and the regulation of energy balance
por: Cansell, Céline, et al.
Publicado: (2012)

Dynamic GABAergic afferent modulation of AgRP neurons
por: Garfield, Alastair S, et al.
Publicado: (2016)

Beneficial metabolic role of β-arrestin-1 expressed by AgRP neurons
por: Pydi, Sai P., et al.
Publicado: (2020)

Beneficial Effects of Metformin and/or Salicylate on Palmitate- or TNFα-Induced Neuroinflammatory Marker and Neuropeptide Gene Regulation in Immortalized NPY/AgRP Neurons
por: Ye, Wenqing, et al.
Publicado: (2016)

Involvement of CD36 in Modulating the Decrease of NPY and AgRP Induced by Acute Palmitic Acid Stimulation in N1E-115 Cells
por: Ma, Yan, et al.
Publicado: (2017)

Ablation of AgRP neurons impairs adaption to restricted feeding
por: Tan, Keith, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_mhsd24vs22p8rvoaim79h3f5p6