Fumarase affects the deoxyribonucleic acid damage response by protecting the mitochondrial desulfurase Nfs1p from modification and inactivation

The Krebs cycle enzyme fumarase, which has been identified as a tumor suppressor, is involved in the deoxyribonucleic acid (DNA) damage response (DDR) in human, yeast, and bacterial cells. We have found that the overexpression of the cysteine desulfurase Nfs1p restores DNA repair in fumarase-deficie...

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Detalles Bibliográficos
Autores principales: Yip, Joyce, Wang, Suqing, Tan, Jasper, Lim, Teck Kwang, Lin, Qingsong, Yu, Zhang, Karmon, Ofri, Pines, Ophry, Lehming, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590083/
https://www.ncbi.nlm.nih.gov/pubmed/34805801
http://dx.doi.org/10.1016/j.isci.2021.103354

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