Metabolic reprogramming mediates hippocampal microglial M1 polarization in response to surgical trauma causing perioperative neurocognitive disorders

BACKGROUND: Microglial polarization toward pro-inflammatory M1 phenotype are major contributors to the development of perioperative neurocognitive disorders (PNDs). Metabolic reprogramming plays an important role in regulating microglial polarization. We therefore hypothesized that surgical trauma c...

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Detalles Bibliográficos
Autores principales: Luo, Gang, Wang, Xiaofeng, Cui, Yongchen, Cao, Yue, Zhao, Zhe, Zhang, Junfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590219/
https://www.ncbi.nlm.nih.gov/pubmed/34774071
http://dx.doi.org/10.1186/s12974-021-02318-5

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