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Dnmt3a is downregulated by Stat5a and mediates G0/G1 arrest by suppressing the miR-17-5p/Cdkn1a axis in Jak2(V617F) cells

BACKGROUND: Despite of the frequently reported Dnmt3a abormality in classical myeloproliferative neoplasms (cMPNs) patients, few research explores how the Dnmt3a is regulated by Jak2(V617F) mutation. In this study, we have investigated how the Dnmt3a is regulated by Jak2(V617F) mutation and its effe...

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Detalles Bibliográficos
Autores principales:	Zhou, Jie, Guo, Cheng, Wu, Hao, Li, Bing, Zhou, Li-Li, Liang, Ai-Bin, Fu, Jian-Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590245/ https://www.ncbi.nlm.nih.gov/pubmed/34773997 http://dx.doi.org/10.1186/s12885-021-08915-0

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