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A Systematic Review of the Use of St. John’s Wort for Smoking Cessation in Adults

St. John’s wort (SJW) has been researched and clinically used for treating various psychiatric disorders, including depression. Few clinical trials have studied its use in smoking cessation. This systematic review provides comprehensive evidence of the studies conducted to date. Five databases were...

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Detalles Bibliográficos
Autores principales: Walia, Namrata, Gonzalez, Sandra, Zoorob, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590314/
https://www.ncbi.nlm.nih.gov/pubmed/34796061
http://dx.doi.org/10.7759/cureus.18769
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author Walia, Namrata
Gonzalez, Sandra
Zoorob, Roger
author_facet Walia, Namrata
Gonzalez, Sandra
Zoorob, Roger
author_sort Walia, Namrata
collection PubMed
description St. John’s wort (SJW) has been researched and clinically used for treating various psychiatric disorders, including depression. Few clinical trials have studied its use in smoking cessation. This systematic review provides comprehensive evidence of the studies conducted to date. Five databases were searched for randomized controlled trials (RCTs) that evaluated the effectiveness of SJW for smoking cessation in adults. The trials included the use of SJW alone, or along with nicotine replacement therapy, chromium, or behavioral therapies. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used to report this systematic review. Overall, four RCTs met the eligibility criteria, and the risk of bias analysis was conducted using the Cochrane criteria. Abstinence, along with other physical symptoms, were measured as outcomes at the end of the follow-up period. Studies reported variable abstinence rates and a decrease in cravings at the end of 12-14 weeks. However, there was minimal to no difference reported between the intervention and placebo groups in all of the clinical trials. One of the studies reported minimal physical side effects. Overall, SJW was well tolerated. Quality analysis of the included studies showed low concerns in two studies while the other two studies showed high concerns in the risk of bias judgment. More clinical trials with larger sample sizes should be conducted in the future to evaluate the effectiveness of the use of SJW for smoking cessation.
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spelling pubmed-85903142021-11-17 A Systematic Review of the Use of St. John’s Wort for Smoking Cessation in Adults Walia, Namrata Gonzalez, Sandra Zoorob, Roger Cureus Preventive Medicine St. John’s wort (SJW) has been researched and clinically used for treating various psychiatric disorders, including depression. Few clinical trials have studied its use in smoking cessation. This systematic review provides comprehensive evidence of the studies conducted to date. Five databases were searched for randomized controlled trials (RCTs) that evaluated the effectiveness of SJW for smoking cessation in adults. The trials included the use of SJW alone, or along with nicotine replacement therapy, chromium, or behavioral therapies. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used to report this systematic review. Overall, four RCTs met the eligibility criteria, and the risk of bias analysis was conducted using the Cochrane criteria. Abstinence, along with other physical symptoms, were measured as outcomes at the end of the follow-up period. Studies reported variable abstinence rates and a decrease in cravings at the end of 12-14 weeks. However, there was minimal to no difference reported between the intervention and placebo groups in all of the clinical trials. One of the studies reported minimal physical side effects. Overall, SJW was well tolerated. Quality analysis of the included studies showed low concerns in two studies while the other two studies showed high concerns in the risk of bias judgment. More clinical trials with larger sample sizes should be conducted in the future to evaluate the effectiveness of the use of SJW for smoking cessation. Cureus 2021-10-14 /pmc/articles/PMC8590314/ /pubmed/34796061 http://dx.doi.org/10.7759/cureus.18769 Text en Copyright © 2021, Walia et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Preventive Medicine
Walia, Namrata
Gonzalez, Sandra
Zoorob, Roger
A Systematic Review of the Use of St. John’s Wort for Smoking Cessation in Adults
title A Systematic Review of the Use of St. John’s Wort for Smoking Cessation in Adults
title_full A Systematic Review of the Use of St. John’s Wort for Smoking Cessation in Adults
title_fullStr A Systematic Review of the Use of St. John’s Wort for Smoking Cessation in Adults
title_full_unstemmed A Systematic Review of the Use of St. John’s Wort for Smoking Cessation in Adults
title_short A Systematic Review of the Use of St. John’s Wort for Smoking Cessation in Adults
title_sort systematic review of the use of st. john’s wort for smoking cessation in adults
topic Preventive Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590314/
https://www.ncbi.nlm.nih.gov/pubmed/34796061
http://dx.doi.org/10.7759/cureus.18769
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