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Fluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults

PURPOSE: To evaluate the effect of fluctuations in waist circumference (WC), weight, and body mass index (BMI) on the incidence of diabetes in older adults. PATIENTS AND METHODS: A prospective cohort of 61,587 older adults (age, 60–96 years) who did not have diabetes at study initiation was examined...

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Autores principales: Wu, Linna, Liu, Hongyan, Cui, Zhuang, Hou, Fang, Gong, Xiaowen, Zhang, Yourui, Lu, Chunlan, Liu, Hao, Yu, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590369/
https://www.ncbi.nlm.nih.gov/pubmed/34774072
http://dx.doi.org/10.1186/s12986-021-00627-3
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author Wu, Linna
Liu, Hongyan
Cui, Zhuang
Hou, Fang
Gong, Xiaowen
Zhang, Yourui
Lu, Chunlan
Liu, Hao
Yu, Pei
author_facet Wu, Linna
Liu, Hongyan
Cui, Zhuang
Hou, Fang
Gong, Xiaowen
Zhang, Yourui
Lu, Chunlan
Liu, Hao
Yu, Pei
author_sort Wu, Linna
collection PubMed
description PURPOSE: To evaluate the effect of fluctuations in waist circumference (WC), weight, and body mass index (BMI) on the incidence of diabetes in older adults. PATIENTS AND METHODS: A prospective cohort of 61,587 older adults (age, 60–96 years) who did not have diabetes at study initiation was examined. Data on weight, BMI, and WC were collected, and participants were followed up until 31 December 2018. The main end point was new-onset diabetes. A Cox regression model was used to estimate the risk of diabetes (hazard ratios [HRs] and confidence intervals [CI]) in these participants. RESULTS: During a mean follow-up of 3.6 years, being overweight (HR [95% CI] 1.87 [1.62–2.17]), obesity (1.41 [1.26–1.59]), abdominal obesity (1.42 [1.28–1.58]), and obesity plus abdominal obesity at baseline (1.93 [1.66–2.25]) increased the risk of diabetes onset. Compared with older adults who “maintained normal WC”, those who “remained abdominally obese” (HR = 1.66), “became abdominally obese” (HR = 1.58), or “achieved normal WC” (HR = 1.36) were at a higher risk of diabetes onset, as well as those with an increase in WC > 3 cm or > 5% compared with the baseline level. Weight gain or loss > 6 kg or weight gain > 5%, increase or decrease in BMI > 2 kg/m(2), or an increase in BMI > 10% were associated with a higher diabetes risk. The diabetes risk was reduced by 19% in overweight older adults who exercised daily. CONCLUSION: For older adults, WC, BMI, and healthy weight maintenance reduce the diabetes risk. The findings may provide evidence for developing guidelines of proper weight and WC control for older adults.
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spelling pubmed-85903692021-11-15 Fluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults Wu, Linna Liu, Hongyan Cui, Zhuang Hou, Fang Gong, Xiaowen Zhang, Yourui Lu, Chunlan Liu, Hao Yu, Pei Nutr Metab (Lond) Research PURPOSE: To evaluate the effect of fluctuations in waist circumference (WC), weight, and body mass index (BMI) on the incidence of diabetes in older adults. PATIENTS AND METHODS: A prospective cohort of 61,587 older adults (age, 60–96 years) who did not have diabetes at study initiation was examined. Data on weight, BMI, and WC were collected, and participants were followed up until 31 December 2018. The main end point was new-onset diabetes. A Cox regression model was used to estimate the risk of diabetes (hazard ratios [HRs] and confidence intervals [CI]) in these participants. RESULTS: During a mean follow-up of 3.6 years, being overweight (HR [95% CI] 1.87 [1.62–2.17]), obesity (1.41 [1.26–1.59]), abdominal obesity (1.42 [1.28–1.58]), and obesity plus abdominal obesity at baseline (1.93 [1.66–2.25]) increased the risk of diabetes onset. Compared with older adults who “maintained normal WC”, those who “remained abdominally obese” (HR = 1.66), “became abdominally obese” (HR = 1.58), or “achieved normal WC” (HR = 1.36) were at a higher risk of diabetes onset, as well as those with an increase in WC > 3 cm or > 5% compared with the baseline level. Weight gain or loss > 6 kg or weight gain > 5%, increase or decrease in BMI > 2 kg/m(2), or an increase in BMI > 10% were associated with a higher diabetes risk. The diabetes risk was reduced by 19% in overweight older adults who exercised daily. CONCLUSION: For older adults, WC, BMI, and healthy weight maintenance reduce the diabetes risk. The findings may provide evidence for developing guidelines of proper weight and WC control for older adults. BioMed Central 2021-11-13 /pmc/articles/PMC8590369/ /pubmed/34774072 http://dx.doi.org/10.1186/s12986-021-00627-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wu, Linna
Liu, Hongyan
Cui, Zhuang
Hou, Fang
Gong, Xiaowen
Zhang, Yourui
Lu, Chunlan
Liu, Hao
Yu, Pei
Fluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults
title Fluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults
title_full Fluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults
title_fullStr Fluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults
title_full_unstemmed Fluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults
title_short Fluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults
title_sort fluctuations in waist circumference increase diabetes risk: a 4-year cohort study in 61,587 older adults
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590369/
https://www.ncbi.nlm.nih.gov/pubmed/34774072
http://dx.doi.org/10.1186/s12986-021-00627-3
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