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Anticholinergic drug use in elderly people: A population- based study in Iran

BACKGROUND: Elderly people are in need of several drugs due to physiological changes and multiple chronic diseases. Studies have shown that anticholinergic drugs can cause cognitive impairment, reduced physical activity, and increased mortality in elderly population. Paying attention to the antichol...

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Autores principales: Raei, Kimia, Rahimi, Atena, Hosseini, Seyed Reza, Moghadamnia, Ali Akbar, Bijani, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590416/
https://www.ncbi.nlm.nih.gov/pubmed/34820068
http://dx.doi.org/10.22088/cjim.12.4.593
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author Raei, Kimia
Rahimi, Atena
Hosseini, Seyed Reza
Moghadamnia, Ali Akbar
Bijani, Ali
author_facet Raei, Kimia
Rahimi, Atena
Hosseini, Seyed Reza
Moghadamnia, Ali Akbar
Bijani, Ali
author_sort Raei, Kimia
collection PubMed
description BACKGROUND: Elderly people are in need of several drugs due to physiological changes and multiple chronic diseases. Studies have shown that anticholinergic drugs can cause cognitive impairment, reduced physical activity, and increased mortality in elderly population. Paying attention to the anticholinergic medication use in older adults can prevent the occurrence of adverse events and increase the quality of health care. This study was conducted to quantify exposure to anticholinergic medicines in older people in Amirkola. METHODS: This study is a part of the comprehensive cohort project that was being conducted from 2011 on the case patients of 60 years and above that referred to the Amirkola Health Center. A total of 1532 individuals were included, of whom 54.9% were men. The drug information was obtained by observing the patient’s prescription and self-report questionnaires and collected data were analyzed by SPSS software. Exposure to anticholinergic medications was measured using the drug burden index-anticholinergic (DBI-Ach) and the anticholinergic drug scale (ADS). RESULTS: Among the 1532 elderly people with an average age of 69.21 years, 29% had DBI>0 and 36.3% had ADS>0. Also, there was a significant correlation between DBI and ADS (R=0.758). In addition, there is a significant relationship between sex variable with DBI and ADS (P=0.0001). So, women in comparison with men had higher values of DBI and ADS. CONCLUSION: The findings of this study indicate that anticholinergic exposure is relatively high especially in older women, which posed special precautions to avoid inappropriate prescribing in the elderly.
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spelling pubmed-85904162021-11-23 Anticholinergic drug use in elderly people: A population- based study in Iran Raei, Kimia Rahimi, Atena Hosseini, Seyed Reza Moghadamnia, Ali Akbar Bijani, Ali Caspian J Intern Med Original Article BACKGROUND: Elderly people are in need of several drugs due to physiological changes and multiple chronic diseases. Studies have shown that anticholinergic drugs can cause cognitive impairment, reduced physical activity, and increased mortality in elderly population. Paying attention to the anticholinergic medication use in older adults can prevent the occurrence of adverse events and increase the quality of health care. This study was conducted to quantify exposure to anticholinergic medicines in older people in Amirkola. METHODS: This study is a part of the comprehensive cohort project that was being conducted from 2011 on the case patients of 60 years and above that referred to the Amirkola Health Center. A total of 1532 individuals were included, of whom 54.9% were men. The drug information was obtained by observing the patient’s prescription and self-report questionnaires and collected data were analyzed by SPSS software. Exposure to anticholinergic medications was measured using the drug burden index-anticholinergic (DBI-Ach) and the anticholinergic drug scale (ADS). RESULTS: Among the 1532 elderly people with an average age of 69.21 years, 29% had DBI>0 and 36.3% had ADS>0. Also, there was a significant correlation between DBI and ADS (R=0.758). In addition, there is a significant relationship between sex variable with DBI and ADS (P=0.0001). So, women in comparison with men had higher values of DBI and ADS. CONCLUSION: The findings of this study indicate that anticholinergic exposure is relatively high especially in older women, which posed special precautions to avoid inappropriate prescribing in the elderly. Babol University of Medical Sciences 2021 /pmc/articles/PMC8590416/ /pubmed/34820068 http://dx.doi.org/10.22088/cjim.12.4.593 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Raei, Kimia
Rahimi, Atena
Hosseini, Seyed Reza
Moghadamnia, Ali Akbar
Bijani, Ali
Anticholinergic drug use in elderly people: A population- based study in Iran
title Anticholinergic drug use in elderly people: A population- based study in Iran
title_full Anticholinergic drug use in elderly people: A population- based study in Iran
title_fullStr Anticholinergic drug use in elderly people: A population- based study in Iran
title_full_unstemmed Anticholinergic drug use in elderly people: A population- based study in Iran
title_short Anticholinergic drug use in elderly people: A population- based study in Iran
title_sort anticholinergic drug use in elderly people: a population- based study in iran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590416/
https://www.ncbi.nlm.nih.gov/pubmed/34820068
http://dx.doi.org/10.22088/cjim.12.4.593
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