Cargando…

In depth analysis of Cyprus-specific mutations of SARS-CoV-2 strains using computational approaches

BACKGROUND: This study aims to characterize SARS-CoV-2 mutations which are primarily prevalent in the Cypriot population. Moreover, using computational approaches, we assess whether these mutations are associated with changes in viral virulence. METHODS: We utilize genetic data from 144 sequences of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oulas, Anastasis, Richter, Jan, Zanti, Maria, Tomazou, Marios, Michailidou, Kyriaki, Christodoulou, Kyproula, Christodoulou, Christina, Spyrou, George M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590444/ https://www.ncbi.nlm.nih.gov/pubmed/34773976 http://dx.doi.org/10.1186/s12863-021-01007-9

Ejemplares similares

Generalized linear models provide a measure of virulence for specific mutations in SARS-CoV-2 strains
por: Oulas, Anastasis, et al.
Publicado: (2021)

Molecular epidemiology of SARS-CoV-2 in Cyprus
por: Richter, Jan, et al.
Publicado: (2021)

Performance evaluation of pipelines for mapping, variant calling and interval padding, for the analysis of NGS germline panels
por: Zanti, Maria, et al.
Publicado: (2021)

Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19
por: Tomazou, Marios, et al.
Publicado: (2021)

Analyzing Gene Expression Profiles from Ataxia and Spasticity Phenotypes to Reveal Spastic Ataxia Related Pathways
por: Kakouri, Andrea C., et al.
Publicado: (2020)

In Silico Identification of Antimicrobial Peptides in the Proteomes of Goat and Sheep Milk and Feta Cheese
por: Tomazou, Marios, et al.
Publicado: (2019)

Bacterial Wars—a tool for the prediction of bacterial predominance based on network analysis measures
por: Oulas, Anastasis, et al.
Publicado: (2023)

Molecular epidemiology of enteroviruses in Cyprus 2008-2017
por: Richter, Jan, et al.
Publicado: (2019)

NGS Panel Testing of Triple-Negative Breast Cancer Patients in Cyprus: A Study of BRCA-Negative Cases
por: Zanti, Maria, et al.
Publicado: (2020)

Comparative analysis of affected and unaffected areas of systemic sclerosis skin biopsies by high-throughput proteomic approaches
por: Chairta, Paraskevi, et al.
Publicado: (2020)

Introduction, Spread and Impact of the SARS-CoV-2 Omicron Variants BA.1 and BA.2 in Cyprus
por: Richter, Jan, et al.
Publicado: (2022)

Putative Antimicrobial Peptides Within Bacterial Proteomes Affect Bacterial Predominance: A Network Analysis Perspective
por: Oulas, Anastasis, et al.
Publicado: (2021)

Type 2 Diabetes Susceptibility in the Greek-Cypriot Population: Replication of Associations with TCF7L2, FTO, HHEX, SLC30A8 and IGF2BP2 Polymorphisms
por: Votsi, Christina, et al.
Publicado: (2017)

10th International Multithematic Scientific Bio-Medical Congress (IMBMC), Nicosia, Cyprus, 2022
por: Christodoulou, Panayiota, et al.
Publicado: (2023)

Genetic Susceptibility to Systemic Sclerosis in the Greek-Cypriot Population: A Pilot Study
por: Chairta, Paraskevi, et al.
Publicado: (2020)

Transcriptomic characterization of tissues from patients and subsequent pathway analyses reveal biological pathways that are implicated in spastic ataxia
por: Kakouri, Andrea C., et al.
Publicado: (2022)

The Impact of the COVID-19 Pandemic on Mental Health: Evidence from Cyprus
por: Mousoulidou, Marilena, et al.
Publicado: (2021)

Dysbiosis and Enhanced Beta-Defensin Production in Hair Follicles of Patients with Lichen Planopilaris and Frontal Fibrosing Alopecia
por: Constantinou, Andria, et al.
Publicado: (2021)

PathIN: an integrated tool for the visualization of pathway interaction networks()
por: Minadakis, George, et al.
Publicado: (2022)

Aetiology of Acute Respiratory Tract Infections in Hospitalised Children in Cyprus
por: Richter, Jan, et al.
Publicado: (2016)

Conspiracy Theories, Trust in Science, and Knowledge during the Third Wave of the COVID-19 Pandemic in Cyprus
por: Mousoulidou, Marilena, et al.
Publicado: (2023)

Methylation status of hypothalamic Mkrn3 promoter across puberty
por: Fanis, Pavlos, et al.
Publicado: (2023)

Aetiology of Community-Acquired Pneumonia and the Role of Genetic Host Factors in Hospitalized Patients in Cyprus
por: Ladas, Petros, et al.
Publicado: (2023)

The Role of Conspiracy Theories, Perceived Risk, and Trust in Science on COVID-19 Vaccination Decisiveness: Evidence from Cyprus
por: Mousoulidou, Marilena, et al.
Publicado: (2023)

Systems Bioinformatics: increasing precision of computational diagnostics and therapeutics through network-based approaches
por: Oulas, Anastasis, et al.
Publicado: (2017)

PathwayConnector: finding complementary pathways to enhance functional analysis
por: Minadakis, George, et al.
Publicado: (2019)

Selecting variants of unknown significance through network-based gene-association significantly improves risk prediction for disease-control cohorts
por: Oulas, Anastasis, et al.
Publicado: (2019)

Investigating the Transition of Pre-Symptomatic to Symptomatic Huntington’s Disease Status Based on Omics Data
por: Christodoulou, Christiana C., et al.
Publicado: (2020)

Complete Genome Sequence of West Nile Virus (WNV) from the First Human Case of Neuroinvasive WNV Infection in Cyprus
por: Richter, Jan, et al.
Publicado: (2017)

Exposure to airborne SARS-CoV-2 in four hospital wards and ICUs of Cyprus. A detailed study accounting for day-to-day operations and aerosol generating procedures
por: Konatzii, Rafail, et al.
Publicado: (2023)

Macrofaunal assemblages associated with the sponge Sarcotragus foetidus Schmidt, 1862 (Porifera: Demospongiae) at the coasts of Cyprus and Greece
por: Pavloudi, Christina, et al.
Publicado: (2016)

Selective Delivery to Cardiac Muscle Cells Using Cell-Specific Aptamers
por: Philippou, Styliana, et al.
Publicado: (2023)

7th International Multithematic Scientific Bio-Medical Congress (IMBMC), Nicosia, Cyprus, 2019
por: Christodoulou, Panayiota, et al.
Publicado: (2020)

Land use in urban areas impacts the composition of soil bacterial communities involved in nitrogen cycling. A case study from Lefkosia (Nicosia) Cyprus
por: Stephanou, Coralea, et al.
Publicado: (2021)

Effect of HBB genotype on survival in a cohort of transfusion-dependent thalassemia patients in Cyprus
por: Kountouris, Petros, et al.
Publicado: (2020)

A novel c.5308_5311delGAGA mutation in Senataxin in a Cypriot family with an autosomal recessive cerebellar ataxia
por: Nicolaou, Paschalis, et al.
Publicado: (2008)

4th International Multithematic Scientific Bio-Medical Congress, Cyprus 2016
por: Stephanou, Anastasis, et al.
Publicado: (2017)

Genomic Epidemiology of the SARS-CoV-2 Epidemic in Cyprus from November 2020 to October 2021: The Passage of Waves of Alpha and Delta Variants of Concern
por: Chrysostomou, Andreas C., et al.
Publicado: (2022)

Vir2Drug: a drug repurposing framework based on protein similarities between pathogens
por: Minadakis, George, et al.
Publicado: (2022)

Biochemical Characterization of the GBA2 c.1780G>C Missense Mutation in Lymphoblastoid Cells from Patients with Spastic Ataxia
por: Malekkou, Anna, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_87impiern8thd974vcrjpas082