Cargando…
Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study
Context Progressive supranuclear palsy (PSP) is a neurodegenerative disorder which comes under Parkinsonism plus syndrome. As this spectrum of disease has many overlapping clinical as well as imaging findings, some quantitative parameters like magnetic resonance Parkinsonism index and midbrain/pons...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2021
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590582/ https://www.ncbi.nlm.nih.gov/pubmed/34790303 http://dx.doi.org/10.1055/s-0041-1736402 |
_version_ | 1784599007248515072 |
---|---|
author | Janarthanan, Vasanthapriya Nadhamuni, Kulasekaran Rajakumar, Sibhithran Padmanaban, Elamparidhi Amirthalingam, Umamageswari Achantani, Yashkumar |
author_facet | Janarthanan, Vasanthapriya Nadhamuni, Kulasekaran Rajakumar, Sibhithran Padmanaban, Elamparidhi Amirthalingam, Umamageswari Achantani, Yashkumar |
author_sort | Janarthanan, Vasanthapriya |
collection | PubMed |
description | Context Progressive supranuclear palsy (PSP) is a neurodegenerative disorder which comes under Parkinsonism plus syndrome. As this spectrum of disease has many overlapping clinical as well as imaging findings, some quantitative parameters like magnetic resonance Parkinsonism index and midbrain/pons ratio are useful to differentiate PSP from other PD patients. Aims The study aimed to detect sensitivity and specificity of magnetic resonance Parkinsonism index in differentiating PSP from PD. Settings and Design It was a retrospective case–control study conducted in Sri Manankula Vinayagar Medical College, Puducherry, during the period of January 2018 to June 2019. Materials and Methods The 87 subjects, who were diagnosed and grouped into three categories (PSP, PD, and control) after performing magnetic resonance imaging brain, were reviewed. The parameters like the area of Pons and midbrain, width of MCP and SCP, P/M, M/P, and MRPI were calculated. Statistical Analysis One-way ANOVA and Chi-square test was used. The sensitivity, specificity, diagnostic accuracy, and cut-off values obtained with receiver operating characteristic curve analysis were determined. Results The mean age of presentation was approximately 75 years with male predominance. The cut-off value of MRPI obtained in this study was 13.4 with 100% sensitivity and specificity. Even though M/P ratio was found to be statistically significant among PSP patients; cut-off value was not obtained. Conclusion MRPI was concluded as the better tool in diagnosing PSP compared with the M/P ratio. Hence the combined qualitative as well as quantitative measurement of MRPI will increase the diagnostic accuracy of PSP. |
format | Online Article Text |
id | pubmed-8590582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85905822021-11-16 Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study Janarthanan, Vasanthapriya Nadhamuni, Kulasekaran Rajakumar, Sibhithran Padmanaban, Elamparidhi Amirthalingam, Umamageswari Achantani, Yashkumar Indian J Radiol Imaging Context Progressive supranuclear palsy (PSP) is a neurodegenerative disorder which comes under Parkinsonism plus syndrome. As this spectrum of disease has many overlapping clinical as well as imaging findings, some quantitative parameters like magnetic resonance Parkinsonism index and midbrain/pons ratio are useful to differentiate PSP from other PD patients. Aims The study aimed to detect sensitivity and specificity of magnetic resonance Parkinsonism index in differentiating PSP from PD. Settings and Design It was a retrospective case–control study conducted in Sri Manankula Vinayagar Medical College, Puducherry, during the period of January 2018 to June 2019. Materials and Methods The 87 subjects, who were diagnosed and grouped into three categories (PSP, PD, and control) after performing magnetic resonance imaging brain, were reviewed. The parameters like the area of Pons and midbrain, width of MCP and SCP, P/M, M/P, and MRPI were calculated. Statistical Analysis One-way ANOVA and Chi-square test was used. The sensitivity, specificity, diagnostic accuracy, and cut-off values obtained with receiver operating characteristic curve analysis were determined. Results The mean age of presentation was approximately 75 years with male predominance. The cut-off value of MRPI obtained in this study was 13.4 with 100% sensitivity and specificity. Even though M/P ratio was found to be statistically significant among PSP patients; cut-off value was not obtained. Conclusion MRPI was concluded as the better tool in diagnosing PSP compared with the M/P ratio. Hence the combined qualitative as well as quantitative measurement of MRPI will increase the diagnostic accuracy of PSP. Thieme Medical and Scientific Publishers Pvt. Ltd. 2021-11-13 /pmc/articles/PMC8590582/ /pubmed/34790303 http://dx.doi.org/10.1055/s-0041-1736402 Text en Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited. |
spellingShingle | Janarthanan, Vasanthapriya Nadhamuni, Kulasekaran Rajakumar, Sibhithran Padmanaban, Elamparidhi Amirthalingam, Umamageswari Achantani, Yashkumar Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study |
title | Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study |
title_full | Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study |
title_fullStr | Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study |
title_full_unstemmed | Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study |
title_short | Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study |
title_sort | accuracy of magnetic resonance parkinsonism index in differentiating progressive supranuclear palsy from parkinson's disease among south indian population: a retrospective case control study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590582/ https://www.ncbi.nlm.nih.gov/pubmed/34790303 http://dx.doi.org/10.1055/s-0041-1736402 |
work_keys_str_mv | AT janarthananvasanthapriya accuracyofmagneticresonanceparkinsonismindexindifferentiatingprogressivesupranuclearpalsyfromparkinsonsdiseaseamongsouthindianpopulationaretrospectivecasecontrolstudy AT nadhamunikulasekaran accuracyofmagneticresonanceparkinsonismindexindifferentiatingprogressivesupranuclearpalsyfromparkinsonsdiseaseamongsouthindianpopulationaretrospectivecasecontrolstudy AT rajakumarsibhithran accuracyofmagneticresonanceparkinsonismindexindifferentiatingprogressivesupranuclearpalsyfromparkinsonsdiseaseamongsouthindianpopulationaretrospectivecasecontrolstudy AT padmanabanelamparidhi accuracyofmagneticresonanceparkinsonismindexindifferentiatingprogressivesupranuclearpalsyfromparkinsonsdiseaseamongsouthindianpopulationaretrospectivecasecontrolstudy AT amirthalingamumamageswari accuracyofmagneticresonanceparkinsonismindexindifferentiatingprogressivesupranuclearpalsyfromparkinsonsdiseaseamongsouthindianpopulationaretrospectivecasecontrolstudy AT achantaniyashkumar accuracyofmagneticresonanceparkinsonismindexindifferentiatingprogressivesupranuclearpalsyfromparkinsonsdiseaseamongsouthindianpopulationaretrospectivecasecontrolstudy |