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Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study

Context  Progressive supranuclear palsy (PSP) is a neurodegenerative disorder which comes under Parkinsonism plus syndrome. As this spectrum of disease has many overlapping clinical as well as imaging findings, some quantitative parameters like magnetic resonance Parkinsonism index and midbrain/pons...

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Autores principales: Janarthanan, Vasanthapriya, Nadhamuni, Kulasekaran, Rajakumar, Sibhithran, Padmanaban, Elamparidhi, Amirthalingam, Umamageswari, Achantani, Yashkumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590582/
https://www.ncbi.nlm.nih.gov/pubmed/34790303
http://dx.doi.org/10.1055/s-0041-1736402
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author Janarthanan, Vasanthapriya
Nadhamuni, Kulasekaran
Rajakumar, Sibhithran
Padmanaban, Elamparidhi
Amirthalingam, Umamageswari
Achantani, Yashkumar
author_facet Janarthanan, Vasanthapriya
Nadhamuni, Kulasekaran
Rajakumar, Sibhithran
Padmanaban, Elamparidhi
Amirthalingam, Umamageswari
Achantani, Yashkumar
author_sort Janarthanan, Vasanthapriya
collection PubMed
description Context  Progressive supranuclear palsy (PSP) is a neurodegenerative disorder which comes under Parkinsonism plus syndrome. As this spectrum of disease has many overlapping clinical as well as imaging findings, some quantitative parameters like magnetic resonance Parkinsonism index and midbrain/pons ratio are useful to differentiate PSP from other PD patients. Aims  The study aimed to detect sensitivity and specificity of magnetic resonance Parkinsonism index in differentiating PSP from PD. Settings and Design  It was a retrospective case–control study conducted in Sri Manankula Vinayagar Medical College, Puducherry, during the period of January 2018 to June 2019. Materials and Methods  The 87 subjects, who were diagnosed and grouped into three categories (PSP, PD, and control) after performing magnetic resonance imaging brain, were reviewed. The parameters like the area of Pons and midbrain, width of MCP and SCP, P/M, M/P, and MRPI were calculated. Statistical Analysis  One-way ANOVA and Chi-square test was used. The sensitivity, specificity, diagnostic accuracy, and cut-off values obtained with receiver operating characteristic curve analysis were determined. Results  The mean age of presentation was approximately 75 years with male predominance. The cut-off value of MRPI obtained in this study was 13.4 with 100% sensitivity and specificity. Even though M/P ratio was found to be statistically significant among PSP patients; cut-off value was not obtained. Conclusion  MRPI was concluded as the better tool in diagnosing PSP compared with the M/P ratio. Hence the combined qualitative as well as quantitative measurement of MRPI will increase the diagnostic accuracy of PSP.
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spelling pubmed-85905822021-11-16 Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study Janarthanan, Vasanthapriya Nadhamuni, Kulasekaran Rajakumar, Sibhithran Padmanaban, Elamparidhi Amirthalingam, Umamageswari Achantani, Yashkumar Indian J Radiol Imaging Context  Progressive supranuclear palsy (PSP) is a neurodegenerative disorder which comes under Parkinsonism plus syndrome. As this spectrum of disease has many overlapping clinical as well as imaging findings, some quantitative parameters like magnetic resonance Parkinsonism index and midbrain/pons ratio are useful to differentiate PSP from other PD patients. Aims  The study aimed to detect sensitivity and specificity of magnetic resonance Parkinsonism index in differentiating PSP from PD. Settings and Design  It was a retrospective case–control study conducted in Sri Manankula Vinayagar Medical College, Puducherry, during the period of January 2018 to June 2019. Materials and Methods  The 87 subjects, who were diagnosed and grouped into three categories (PSP, PD, and control) after performing magnetic resonance imaging brain, were reviewed. The parameters like the area of Pons and midbrain, width of MCP and SCP, P/M, M/P, and MRPI were calculated. Statistical Analysis  One-way ANOVA and Chi-square test was used. The sensitivity, specificity, diagnostic accuracy, and cut-off values obtained with receiver operating characteristic curve analysis were determined. Results  The mean age of presentation was approximately 75 years with male predominance. The cut-off value of MRPI obtained in this study was 13.4 with 100% sensitivity and specificity. Even though M/P ratio was found to be statistically significant among PSP patients; cut-off value was not obtained. Conclusion  MRPI was concluded as the better tool in diagnosing PSP compared with the M/P ratio. Hence the combined qualitative as well as quantitative measurement of MRPI will increase the diagnostic accuracy of PSP. Thieme Medical and Scientific Publishers Pvt. Ltd. 2021-11-13 /pmc/articles/PMC8590582/ /pubmed/34790303 http://dx.doi.org/10.1055/s-0041-1736402 Text en Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Janarthanan, Vasanthapriya
Nadhamuni, Kulasekaran
Rajakumar, Sibhithran
Padmanaban, Elamparidhi
Amirthalingam, Umamageswari
Achantani, Yashkumar
Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study
title Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study
title_full Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study
title_fullStr Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study
title_full_unstemmed Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study
title_short Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study
title_sort accuracy of magnetic resonance parkinsonism index in differentiating progressive supranuclear palsy from parkinson's disease among south indian population: a retrospective case control study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590582/
https://www.ncbi.nlm.nih.gov/pubmed/34790303
http://dx.doi.org/10.1055/s-0041-1736402
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