Cargando…

Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer

Cetuximab is approved for the treatment of metastatic colorectal cancer (mCRC) with RAS wild-type. Nevertheless, the prognosis remains poor and the effectiveness of cetuximab is limited in KRAS mutant mCRC. Recently, emerging evidence has shown that ferroptosis, a newly discovered form of nonapoptot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Jiawen, Mo, Jiajie, Dai, Juji, Ye, Chenqiao, Cen, Wei, Zheng, Xuzhi, Jiang, Lei, Ye, Lechi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590697/ https://www.ncbi.nlm.nih.gov/pubmed/34775496 http://dx.doi.org/10.1038/s41419-021-04367-3

Ejemplares similares

Combination RSL3 Treatment Sensitizes Ferroptosis- and EGFR-Inhibition-Resistant HNSCCs to Cetuximab
por: Liu, Shujie, et al.
Publicado: (2022)

Low-Concentration PTX And RSL3 Inhibits Tumor Cell Growth Synergistically By Inducing Ferroptosis In Mutant p53 Hypopharyngeal Squamous Carcinoma
por: Ye, Jing, et al.
Publicado: (2019)

Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab
por: Dunn, Emily F., et al.
Publicado: (2010)

PUM1 Is Overexpressed in Colon Cancer Cells With Acquired Resistance to Cetuximab
por: Liu, Qizhi, et al.
Publicado: (2021)

The RSL3 Induction of KLK Lung Adenocarcinoma Cell Ferroptosis by Inhibition of USP11 Activity and the NRF2-GSH Axis
por: Zhang, Wenlong, et al.
Publicado: (2022)

Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis
por: Park, Sujeong, et al.
Publicado: (2018)

RSL3 Inhibits Porcine Epidemic Diarrhea Virus Replication by Activating Ferroptosis
por: Li, Yingguang, et al.
Publicado: (2023)

Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression
por: Cui, Yu, et al.
Publicado: (2021)

Carboxymethylated pachyman induces ferroptosis in ovarian cancer by suppressing NRF1/HO-1 signaling
por: Jing, Tiantian, et al.
Publicado: (2022)

Lipoxygenase‐mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3
por: Shintoku, Ryosuke, et al.
Publicado: (2017)

The ferroptosis inducer RSL3 triggers interictal epileptiform activity in mice cortical neurons
por: Giustizieri, Michela, et al.
Publicado: (2023)

Evaluation of the Combined Effect of Artemisinin and Ferroptosis Inducer RSL3 against Toxoplasma gondii
por: Huang, Mao, et al.
Publicado: (2022)

Combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation
por: Chen, Peng, et al.
Publicado: (2020)

Norcantharidin induces ferroptosis via the suppression of NRF2/HO-1 signaling in ovarian cancer cells
por: Zhu, Xiaoyan, et al.
Publicado: (2022)

RSL1D1 promotes the progression of colorectal cancer through RAN-mediated autophagy suppression
por: Liu, Xunhua, et al.
Publicado: (2022)

RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer
por: Sui, Xinbing, et al.
Publicado: (2018)

Le RSL au CERN
Publicado: (1998)

The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1
por: Cheff, Dorian M., et al.
Publicado: (2023)

Platelet-Vesicles-Encapsulated RSL-3 Enable Anti-Angiogenesis and Induce Ferroptosis to Inhibit Pancreatic Cancer Progress
por: Zhang, Yiyin, et al.
Publicado: (2022)

RSL3 Drives Ferroptosis through NF-κB Pathway Activation and GPX4 Depletion in Glioblastoma
por: Li, Shengbiao, et al.
Publicado: (2021)

Iron supplementation enhances RSL3-induced ferroptosis to treat naïve and prevent castration-resistant prostate cancer
por: Maccarinelli, Federica, et al.
Publicado: (2023)

GPX4 overexpressed non-small cell lung cancer cells are sensitive to RSL3-induced ferroptosis
por: Kim, Joo-Won, et al.
Publicado: (2023)

Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer
por: Deng, Chengmin, et al.
Publicado: (2023)

A Novel Pyroptosis-Associated Gene Signature to Predict Prognosis in Patients with Colorectal Cancer
por: Dai, Juji, et al.
Publicado: (2022)

Vitamin D suppresses ferroptosis and protects against neonatal hypoxic-ischemic encephalopathy by activating the Nrf2/HO-1 pathway
por: Cai, Yueju, et al.
Publicado: (2022)

Levistilide a Induces Ferroptosis by Activating the Nrf2/HO-1 Signaling Pathway in Breast Cancer Cells
por: Jing, Shangwen, et al.
Publicado: (2022)

O-GlcNAcylation enhances sensitivity to RSL3-induced ferroptosis via the YAP/TFRC pathway in liver cancer
por: Zhu, Guoqing, et al.
Publicado: (2021)

Safety and efficacy of the addition of simvastatin to cetuximab in previously treated KRAS mutant metastatic colorectal cancer patients
por: Baas, J. M., et al.
Publicado: (2015)

Postconditioning with Irisin Attenuates Lung Ischemia/Reperfusion Injury by Suppressing Ferroptosis via Induction of the Nrf2/HO-1 Signal Axis
por: Wang, Yun, et al.
Publicado: (2022)

Epithelial Membrane Protein 1 Promotes Sensitivity to RSL3-Induced Ferroptosis and Intensifies Gefitinib Resistance in Head and Neck Cancer
por: Wang, Ying, et al.
Publicado: (2022)

Novel roles for HMGA2 isoforms in regulating oxidative stress and sensitizing to RSL3-Induced ferroptosis in prostate cancer cells
por: Campbell, Taaliah, et al.
Publicado: (2023)

Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutatnt colorectal cancer
por: Chen, Hao, et al.
Publicado: (2022)

Combination of cetuximab and PP242 synergistically suppress the progression of wild-type KRAS colorectal carcinoma
por: Cheng, Lei, et al.
Publicado: (2015)

Detection of KRAS mutant alleles in circulating cell-free tumor DNA in colorectal cancer patients resistant to cetuximab
por: Del Re, Marzia, et al.
Publicado: (2014)

Dynamic alterations of genome and transcriptome in KRAS G13D mutant CRC PDX model treated with cetuximab
por: Zhang, Hangyu, et al.
Publicado: (2020)

Fucoidan Ameliorates Ferroptosis in Ischemia-reperfusion-induced Liver Injury through Nrf2/HO-1/GPX4 Activation
por: Li, Jing-Jing, et al.
Publicado: (2023)

Melatonin Suppresses Ferroptosis Induced by High Glucose via Activation of the Nrf2/HO-1 Signaling Pathway in Type 2 Diabetic Osteoporosis
por: Ma, Hongdong, et al.
Publicado: (2020)

6-Gingerol Alleviates Ferroptosis and Inflammation of Diabetic Cardiomyopathy via the Nrf2/HO-1 Pathway
por: Wu, Shenglin, et al.
Publicado: (2022)

Erastin induces ferroptosis in cervical cancer cells via Nrf2/HO-1 signaling pathway
por: Wei, Xiaoning, et al.
Publicado: (2023)

Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancer
por: Park, Soon Young, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2rgc2fhgv8ovq0cg03v8lve2gi