Cargando…

Triglyceride glucose-body mass index in identifying high-risk groups of pre-diabetes

BACKGROUND: Triglyceride glucose-body mass index (TyG-BMI) has been recommended as an alternative indicator of insulin resistance. However, the association between TyG-BMI and pre-diabetes remains to be elucidated. METHODS: More than 100,000 subjects with normal glucose at baseline received follow-u...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Chunyuan, Yang, Ruijuan, Kuang, Maobin, Yu, Meng, Zhong, Mingchun, Zou, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590771/
https://www.ncbi.nlm.nih.gov/pubmed/34774061
http://dx.doi.org/10.1186/s12944-021-01594-7
Descripción
Sumario:BACKGROUND: Triglyceride glucose-body mass index (TyG-BMI) has been recommended as an alternative indicator of insulin resistance. However, the association between TyG-BMI and pre-diabetes remains to be elucidated. METHODS: More than 100,000 subjects with normal glucose at baseline received follow-up. The main outcome event of concern was pre-diabetes defined according to the diagnostic criteria recommended by the American Diabetes Association (ADA) in 2018 and the World Health Organization (WHO) in 1999. A Cox proportional hazard regression model was used to evaluate the role of TyG-BMI in identifying people at high risk of pre-diabetes. RESULTS: At a mean observation period of 3.1 years, the incidence of pre-diabetes in the cohort was 3.70 and 12.31% according to the WHO and ADA diagnostic criteria for pre-diabetes, respectively. The multivariate Cox regression analysis demonstrated that TyG-BMI was independently positively correlated with pre-diabetes, and there was a special population dependence phenomenon. Among them, non-obese people, women and people under 50 years old had a significantly higher risk of TyG-BMI-related pre-diabetes (P-interaction< 0.05). CONCLUSIONS: These findings suggest that a higher TyG-BMI significantly increases an individual’s risk of pre-diabetes, and this risk is significantly higher in women, non-obese individuals, and individuals younger than 50 years of age. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12944-021-01594-7.